CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033804
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rho/rac guanine nucleotide exchange factor (GEF) 2, isoform CRA_a 
Protein Synonyms/Alias
  
Gene Name
 ARHGEF2 
Gene Synonyms/Alias
 hCG_1996334 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
145QQKAALLKNNTALQSubiquitination[1]
397SKALKLYKELYARDKubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Metal-binding; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1030 AA 
Protein Sequence
MLSKSVPVSG INCLLDRSDT DGNVSQSSAI DLRKRCSQLE GHSGTRVGSS LRQTFSFLSG 60
MTGKAKTREK EKMKEAKDAR YTNGHLFTTI SVSGMTMCYA CNKSITAKEA LICPTCNVTI 120
HNRCKDTLAN CTKVKQKQQK AALLKNNTAL QSVSLRSKTT IRERPSSAIY PSDSFRQSLL 180
GSRRGRSSLS LAKSVSTTNI AGHFNDESPL GLRRILSQST DSLNMRNRTL SVESLIDEEV 240
IYSELMSDFE MDEKDFAADS WSLAVDSSFL QQHKKEVMKQ QDVIYELIQT ELHHVRTLKI 300
MTRLFRTGML EELHLEPGVV QGLFPCVDEL SDIHTRFLSQ LLERRRQALC PGSTRNFVIH 360
RLGDLLISQF SGPSAEQMCK TYSEFCSRHS KALKLYKELY ARDKRFQQFI RKVTRPAVLK 420
RHGVQECILL VTQRITKYPL LISRILQHSH GIEEERQDLT TALGLVKELL SNVDEGIYQL 480
EKGARLQEIY NRMDPRAQTP VPGKGPFGRE ELLRRKLIHD GCLLWKTATG RFKDVLVLLM 540
TDVLVFLQEK DQKYIFPTLD KPSVVSLQNL IVRDIANQEK GMFLISAAPP EMYEVHTASR 600
DDRSTWIRVI QQSVRTCPSR EDFPLIETED EAYLRRIKME LQQKDRALVE LLREKVGLFA 660
EMTHFQAEED GGSGMALPTL PRGLFRSESL ESPRGERLLQ DAIREVEGLK DLLVGPGVEL 720
LLTPREPALP LEPDSGGNTS PGVTANGEAR TFNGSIELCR ADSDSSQRDR NGNQLRSPQE 780
EALQRLVNLY GLLHGLQAAV AQQDTLMEAR FPEGPERREK LCRANSRDGE AGRAGAAPVA 840
PEKQATELAL LQRQHALLQE ELRRCRRLGE ERATEAGSLE ARLRESEQAR ALLEREAEEA 900
RRQLAALGQT EPLPAEAPWA RRPVDPRRRS LPAGDALYLS FNPPQPSRGT DRLDLPVTTR 960
SVHRNFEDRE RQELGSPEER LQDSSDPDTG SEEEGSSRLS PPHSPRDFTR MQDIPEETES 1020
RDGEAVASES 1030 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR015721; RhoGEF-like. 
Pfam
 PF00169; PH
 PF00621; RhoGEF 
SMART
 SM00109; C1
 SM00233; PH
 SM00325; RhoGEF 
PROSITE
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS