UniProt Accession

 WDR82_MOUSE; Q8BFQ4; Q8K2G5; Q8VEE8 

Genbank Protein ID

 AK035109; AK037620; AK149692; EF011615; BC019115; BC031502 

Genbank Nucleotide ID

 BAC28947.1; BAC29836.1; BAE29029.1; ABK41105.1; AAH19115.1; AAH31502.1 

Protein Name

 WD repeat-containing protein 82 

Protein Synonyms/Alias

  

Gene Name

 Wdr82 

Gene Synonyms/Alias

 Cdw5 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
63	KRTLYSKKYGVDLIR	ubiquitination	[1]
84	TVVYSSNKIDDTIRY	ubiquitination	[1]
181	YDLRSFDKGPFATFK	ubiquitination	[1]
280	KVAVLDGKHTGPITC	acetylation	[2]
280	KVAVLDGKHTGPITC	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Possible role in telomere length maintenance and in mRNA processing (By similarity). 

Sequence Annotation

 REPEAT 19 58 WD 1.
 REPEAT 105 144 WD 2.
 REPEAT 146 184 WD 3.
 REPEAT 192 231 WD 4.
 REPEAT 236 276 WD 5.
 REPEAT 280 313 WD 6.
 MOD_RES 154 154 Phosphoserine.  

Keyword

 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 313 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; ISS:UniProtKB.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0072357; C:PTW/PP1 phosphatase complex; ISS:UniProtKB.
 GO:0048188; C:Set1C/COMPASS complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IEA:Compara.
 GO:0051568; P:histone H3-K4 methylation; IMP:MGI. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.