CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040063
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DNA repair protein XRCC1 
Protein Synonyms/Alias
  
Gene Name
 XRCC1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
98EKRWDRVKIVCSQPYubiquitination[1, 2]
107VCSQPYSKDSPFGLSubiquitination[1]
138SQKVTVTKLGQFRVKacetylation[2]
138SQKVTVTKLGQFRVKubiquitination[1, 3]
267AQGAVTGKPRGEGTEacetylation[2]
310FRSELRDKALELGAKubiquitination[1, 2]
338CAFANTPKYSQVLGLubiquitination[4]
352LGGRIVRKEWVLDCHubiquitination[1]
587WIYSCNEKQKLLPHQubiquitination[1]
589YSCNEKQKLLPHQLYubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 602 AA 
Protein Sequence
MPEIRLRHVV SCSSQDSLEK EEQIHSVDIG NDGSAFVEVL VGSSAGGAGE QDYEVLLVTS 60
SFMSPSESRS GSNPNRVRMF GPDKLVRAAA EKRWDRVKIV CSQPYSKDSP FGLSFVRFHS 120
PPDKDEAEAP SQKVTVTKLG QFRVKEEDES ANSLRPGALF FSRINKTSPV TASDPAGPSY 180
AAATLQASSA ASSASPVSRA IGSTSKPQES PKGKRKLDLN QEEKKTPSKP PAQLSPSVPK 240
RPKLPAPTRT PATAPVPARA QGAVTGKPRG EGTEPRRPRA GPEELGKILQ GVVVVLSGFQ 300
NPFRSELRDK ALELGAKYRP DWTRDSTHLI CAFANTPKYS QVLGLGGRIV RKEWVLDCHR 360
MRRRLPSQRY LMAGPGSSSE EDEASHSGGS GDEAPKLPQK QPQTKTKPTQ AAGPSSPQKP 420
PTPEETKAAS PVLQEDIDIE GVQSEGQDNG AEDSGDTEDE LRRVAEQKEH RLPPGQEENG 480
EDPYAGSTDE NTDSEEHQEP PDLPVPELPD FFQGKHFFLY GEFPGDERRK LIRYVTAFNG 540
ELEDNMSDRV QFVITAQEWD PSFEEALMDN PSLAFVRPRW IYSCNEKQKL LPHQLYGVVP 600
QA 602 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003684; F:damaged DNA binding; IEA:InterPro.
 GO:0000012; P:single strand break repair; IEA:InterPro. 
Interpro
 IPR001357; BRCT_dom.
 IPR008979; Galactose-bd-like.
 IPR002706; Xrcc1_N. 
Pfam
 PF00533; BRCT
 PF01834; XRCC1_N 
SMART
 SM00292; BRCT 
PROSITE
 PS50172; BRCT 
PRINTS