CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016839
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Large neutral amino acids transporter small subunit 4 
Protein Synonyms/Alias
 L-type amino acid transporter 4; Solute carrier family 43 member 2 
Gene Name
 Slc43a2 
Gene Synonyms/Alias
 Lat4 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
260FDHKITGKQFYKQVTubiquitination[1]
283GSSMRTAKEQAALQEubiquitination[1]
293AALQEGHKLCLSTVDubiquitination[1]
402TSEEPEEKEGTQGEKubiquitination[1]
557EDSKLFLKINGSSNRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Sodium-, chloride-, and pH-independent, high affinity transport of large neutral amino acids. 
Sequence Annotation
 MOD_RES 274 274 Phosphoserine.
 MOD_RES 278 278 Phosphoserine (By similarity).
 CARBOHYD 55 55 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 568 AA 
Protein Sequence
MAPTLATAHR RRWWMACTAV LENLLFSAVL LGWGSLLIML KSEGFYSYLC TKPENVTNST 60
VGGSAEPEPE ELSLVNGWLS CKAQDEILNL AFTVGSFLLS AITLPLGIIM DKYGPRKLRL 120
LGSACFAVSC LLIAYGASNP DSLSVLIFIA LALNGFGGMC MTFTSLTLPN MFGDLRSTFI 180
ALMIGSYASS AVTFPGIKLI YDAGASFIGI LVVWAGCSGL VFFNCFFNWP LEPFPGPEDM 240
DYSVKIKFSW LGFDHKITGK QFYKQVTTVG RRLSVGSSMR TAKEQAALQE GHKLCLSTVD 300
LEVKCQPDAA AAPSFMHSVF SPLLVLSLVT MCVTQLRLIF YMGAMNSILE FLVRGDQKTV 360
ALYTSIFGAL QLLCLLTAPV IGYIMDWKLK ECEDTSEEPE EKEGTQGEKK QKRDRQIQKV 420
TNAMRAFAFT NVLLVGFGVT CLIPNLPLQI FSFVLHTIVR GFIHSAVGGL YAAVYPSTQF 480
GSLTGLQSLV SALFALLQQP LYLAMMGPLG GDPLWVNVGL LAMSMLGFCL PLYLICYRRQ 540
LERQLQQKRE DSKLFLKING SSNREAFV 568 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0015179; F:L-amino acid transmembrane transporter activity; IDA:MGI. 
Interpro
 IPR027201; LAT4.
 IPR011701; MFS.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR027192; SLC43. 
Pfam
 PF07690; MFS_1 
SMART
  
PROSITE
 PS50850; MFS 
PRINTS