CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019339
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat and calponin homology domain-containing protein 3 
Protein Synonyms/Alias
  
Gene Name
 LRCH3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
229RLDFSCNKITTIPVCubiquitination[1]
494ALQYEEEKIRTKQIQubiquitination[2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
 REPEAT 83 104 LRR 1.
 REPEAT 106 128 LRR 2.
 REPEAT 129 151 LRR 3.
 REPEAT 152 172 LRR 4.
 REPEAT 174 195 LRR 5.
 REPEAT 197 219 LRR 6.
 REPEAT 220 241 LRR 7.
 REPEAT 242 263 LRR 8.
 REPEAT 268 290 LRR 9.
 DOMAIN 652 765 CH.
 MOD_RES 324 324 Phosphoserine.
 MOD_RES 415 415 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Leucine-rich repeat; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 777 AA 
Protein Sequence
MAAAGLVAVA AAAEYSGTVA SGGNLPGVHC GPSSGAGPGF GPGSWSRSLD RALEEAAVTG 60
VLSLSGRKLR EFPRGAANHD LTDTTRADLS RNRLSEIPIE ACHFVSLENL NLYQNCIRYI 120
PEAILNLQAL TFLNISRNQL STLPVHLCNL PLKVLIASNN KLVSLPEEIG HLRHLMELDV 180
SCNEIQTIPS QIGNLEALRD LNVRRNHLVH LPEELAELPL IRLDFSCNKI TTIPVCYRNL 240
RHLQTITLDN NPLQSPPAQI CIKGKVHIFK YLNIQACKIA PDLPDYDRRP LGFGSCHEEL 300
YSSRPYGALD SGFNSVDSGD KRWSGNEPTD EFSDLPLRVA EITKEQRLRR ESQYQENRGS 360
LVVTNGGVEH DLDQIDYIDS CTAEEEEAEV RQPKGPDPDS LSSQFMAYIE QRRISHEGSP 420
VKPVAIREFQ KTEDMRRYLH QNRVPAEPSS LLSLSASHNQ LSHTDLELHQ RREQLVERTR 480
REAQLAALQY EEEKIRTKQI QRDAVLDFVK QKASQSPQKQ HPLLDGVDGE CPFPSRRSQH 540
TDDSALCMSL SGLNQVGCAA TLPHSSAFTP LKSDDRPNAL LSSPATETVH HSPAYSFPAA 600
IQRNQPQRPE SFLFRAGVRA ETNKGHASPL PPSAAPTTDS TDSITGQNSR QREEELELID 660
QLRKHIEYRL KVSLPCDLGA ALTDGVVLCH LANHVRPRSV PSIHVPSPAV PKLTMAKCRR 720
NVENFLEACR KIGVPQDNLC SPSDILQLNL SVKRTVETLL SLGAHSEESS FVCLSLQLLG 780
FVAFYCTVML TLCVLYYWLF PAR 803 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. 
Interpro
 IPR001715; CH-domain.
 IPR001611; Leu-rich_rpt. 
Pfam
 PF00307; CH
 PF00560; LRR_1 
SMART
 SM00033; CH 
PROSITE
 PS50021; CH 
PRINTS