CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014933
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dehydrogenase/reductase SDR family member 7B 
Protein Synonyms/Alias
  
Gene Name
 DHRS7B 
Gene Synonyms/Alias
 CGI-93; UNQ212/PRO238 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
160DTTVDVDKRVMETNYubiquitination[1, 2]
183ALLPSMIKRRQGHIVubiquitination[3, 4]
282DVLAAVGKKKKDVILubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
 Putative oxidoreductase (Potential). 
Sequence Annotation
 NP_BIND 56 80 NAD or NADP (By similarity).
 ACT_SITE 207 207 Proton acceptor (By similarity).
 BINDING 194 194 Substrate (Potential).  
Keyword
 Complete proteome; Membrane; NAD; NADP; Oxidoreductase; Peroxisome; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 325 AA 
Protein Sequence
MVSPATRKSL PKVKAMDFIT STAILPLLFG CLGVFGLFRL LQWVRGKAYL RNAVVVITGA 60
TSGLGKECAK VFYAAGAKLV LCGRNGGALE ELIRELTASH ATKVQTHKPY LVTFDLTDSG 120
AIVAAAAEIL QCFGYVDILV NNAGISYRGT IMDTTVDVDK RVMETNYFGP VALTKALLPS 180
MIKRRQGHIV AISSIQGKMS IPFRSAYAAS KHATQAFFDC LRAEMEQYEI EVTVISPGYI 240
HTNLSVNAIT ADGSRYGVMD TTTAQGRSPV EVAQDVLAAV GKKKKDVILA DLLPSLAVYL 300
RTLAPGLFFS LMASRARKER KSKNS 325 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. 
Interpro
 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 
Pfam
 PF00106; adh_short 
SMART
  
PROSITE
 PS00061; ADH_SHORT 
PRINTS
 PR00081; GDHRDH.
 PR00080; SDRFAMILY.