CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016596
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acetolactate synthase-like protein 
Protein Synonyms/Alias
 IlvB-like protein 
Gene Name
 Ilvbl 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
156AASTLLQKRGALQAIubiquitination[1]
429LRKADQQKEQTYRDKacetylation[2]
594LILSRDNKDQVVKVLacetylation[2]
599DNKDQVVKVLREGQQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
  
Sequence Annotation
 REGION 470 550 Thiamine pyrophosphate binding (By
 METAL 521 521 Magnesium (By similarity).
 METAL 547 547 Magnesium (By similarity).
 BINDING 98 98 Thiamine pyrophosphate (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Magnesium; Membrane; Metal-binding; Reference proteome; Thiamine pyrophosphate; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 632 AA 
Protein Sequence
METSAAAASA GGFFPSFLLL AFGTLVAAVL GVAHRLGLFY QLMHKVDKTS IRHGGESVAA 60
VLRAHGVRFV FTLVGGHISP LLVACEKLGI RVVDTRHEVT AVFAADAVAR LTGTVGVAAV 120
TAGPGLTNTV TAVKNAQVAQ SPVLLLGGAA STLLQKRGAL QAIDQMSLFR PLCKFCASVR 180
RVRDIVPTLR TAIAAAQSGT PGPVFVELPL DVLYPYFMVE KEMIPTKLPN SLMGRVVVWY 240
LQNCLANLFV GAWEPRPEGP LPLDIPQASP QQVQRCVEIL SRAKRPLLVL GSQALLPPTP 300
ANKLRAAVET LGVPCFLGGM SRGLLGRNHP LHIRQNRSAA LKKADVVVLA GAVCDFRLSY 360
GRVLNRKSSI IIVNRNRDDL LLNSDIFWKP QEAVQGDVGS FMIKLVEGLQ GQMWSSDWAE 420
ELRKADQQKE QTYRDKALMP VLQHLNPVWV LQQVEETLPD NALLVVDGGD FVATAAYLVQ 480
PRGPLRWLDP GAFGTLGVGA GFALGAKLCQ PEAEVWCLFG DGAFGYSLIE FDTFVRHKVP 540
VIALVGNDAG WTQISREQVP RLGSDVACSL AYTDYHKAAM GLGAQGLILS RDNKDQVVKV 600
LREGQQLCQD GHAVVVNILI GRTDFRDGSI SV 632 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
 GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
 GO:0008152; P:metabolic process; IEA:GOC. 
Interpro
 IPR012000; Thiamin_PyroP_enz_cen_dom.
 IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
 IPR000399; TPP-bd_CS.
 IPR011766; TPP_enzyme-bd_C. 
Pfam
 PF02775; TPP_enzyme_C
 PF00205; TPP_enzyme_M
 PF02776; TPP_enzyme_N 
SMART
  
PROSITE
 PS00187; TPP_ENZYMES 
PRINTS