CPLM-024307

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-024307

UniProt Accession

FRMD3_HUMAN; A2A2Y4; A8MQB0; B4DN14; Q53EP2; Q5JV59; Q5VZA1; Q86WP8; Q8IZ44; Q8N3Y5; Q8N9L2

Genbank Protein ID

AY137774; AK094281; AK297722; EF560742; AL161786; AL137847; AL161786; AL137847; AL450026; AL137847; AL161786; AL137847; AL161786; AL450026; AL137847; AL161786; AL137847; AL450026; AL450026; AL137847; AL161786; AL450026; AL137847; AL161786; AL137847; AL161786; AL450026; CH471089; CH471089; CH471089; CH471089; BC023560; BC037253; AK223597

Genbank Nucleotide ID

AAN52119.1; BAC04321.1; BAG60076.1; ABQ59052.1; CAH72749.1; CAH72749.1; CAH72750.2; CAH72750.2; CAH72750.2; CAI40734.1; CAI40734.1; CAI40735.2; CAI40735.2; CAI40735.2; CAI40736.1; CAM17460.1; CAM17460.1; CAM17460.1; CAM19643.1; CAM19643.1; CAM19643.1; CAM19644.1; CAM19644.1; CAM19644.1; CAM19673.1; CAM19673.1; CAM19673.1; EAW62647.1; EAW62649.1; EAW62650.1; EAW62651.1; AAH23560.1; AAH37253.1; BAD97317.1

Protein Name

FERM domain-containing protein 3

Protein Synonyms/Alias

Band 4.1-like protein 4O; Ovary type protein 4.1; 4.1O

Gene Name

FRMD3

Gene Synonyms/Alias

EPB41L4O

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
281	IGTQKEKKAMLAFHT	ubiquitination	[1]

Reference

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer.

Sequence Annotation

DOMAIN 32 312 FERM.
MOD_RES 415 415 Phosphoserine (By similarity).

Keyword

Alternative splicing; Complete proteome; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

597 AA

Protein Sequence

MFASCHCVPR GRRTMKMIHF RSSSVKSLSQ EMRCTIRLLD DSEISCHIQR ETKGQFLIDH 60
ICNYYSLLEK DYFGIRYVDP EKQRHWLEPN KSIFKQMKTH PPYTMCFRVK FYPHEPLKIK 120
EELTRYLLYL QIKRDIFHGR LLCSFSDAAY LGACIVQAEL GDYDPDEHPE NYISEFEIFP 180
KQSQKLERKI VEIHKNELRG QSPPVAEFNL LLKAHTLETY GVDPHPCKDS TGTTTFLGFT 240
AAGFVVFQGN KRIHLIKWPD VCKLKFEGKT FYVIGTQKEK KAMLAFHTST PAACKHLWKC 300
GVENQAFYKY AKSSQIKTVS SSKIFFKGSR FRYSGKVAKE VVEASSKIQR EPPEVHRANI 360
TQSRSSHSLN KQLIINMEPL QPLLPSPSEQ EEELPLGEGV PLPKEENISA PLISSSPVKA 420
AREYEDPPSE EEDKIKEEPL TISELVYNPS ASLLPTPVDD DEIDMLFDCP SRLELEREDT 480
DSFEDLEADE NAFLIAEEEE LKEARRALSW SYDILTGHIR VNPLVKSFSR LLVVGLGLLL 540
FVFPLLLLLL ESGIDLSFLC EIRQTPEFEQ FHYEYYCPLK EWVAGKVHLI LYMLGCS 597

Gene Ontology

GO:0005737; C:cytoplasm; IEA:InterPro.
GO:0005856; C:cytoskeleton; IEA:InterPro.
GO:0019898; C:extrinsic to membrane; IEA:InterPro.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.

Interpro

IPR019749; Band_41_domain.
IPR019750; Band_41_fam.
IPR000798; Ez/rad/moesin_like.
IPR014847; FERM-adjacent.
IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748; FERM_central.
IPR019747; FERM_CS.
IPR000299; FERM_domain.
IPR018979; FERM_N.
IPR018980; FERM_PH-like_C.
IPR011993; PH_like_dom.

Pfam

PF08736; FA
PF09380; FERM_C
PF00373; FERM_M
PF09379; FERM_N

SMART

SM00295; B41

PROSITE

PS00660; FERM_1
PS00661; FERM_2
PS50057; FERM_3

PRINTS

PR00935; BAND41.
PR00661; ERMFAMILY.