UniProt Accession

 DGUOK_MOUSE; Q9QX60; Q8CBU2; Q9R0Y2; Q9WUT9 

Genbank Protein ID

 AJ133749; AJ133750; U90524; AK035281; AC090648; CH466523 

Genbank Nucleotide ID

 CAB43121.1; CAB43122.1; AAF14342.1; BAC29014.1; EDK99082.1 

Protein Name

 Deoxyguanosine kinase, mitochondrial 

Protein Synonyms/Alias

 dGK 

Gene Name

 Dguok 

Gene Synonyms/Alias

 Dgk 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
135	GRLLQAEKSVRVFER	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents (By similarity). 

Sequence Annotation

 NP_BIND 45 53 ATP (By similarity).
 NP_BIND 206 208 ATP (By similarity).
 ACT_SITE 141 141 Proton acceptor (Potential).
 BINDING 70 70 Substrate (By similarity).
 BINDING 100 100 Substrate (By similarity).
 BINDING 111 111 Substrate (By similarity).
 BINDING 118 118 Substrate (By similarity).
 BINDING 142 142 Substrate (By similarity).
 BINDING 147 147 Substrate (By similarity).
 BINDING 211 211 Substrate (By similarity).  

Keyword

 Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Mitochondrion; Nucleotide-binding; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 277 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004138; F:deoxyguanosine kinase activity; IDA:MGI.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
 GO:0046070; P:dGTP metabolic process; IDA:MGI.
 GO:0010977; P:negative regulation of neuron projection development; IEA:Compara.
 GO:0006468; P:protein phosphorylation; IDA:MGI.
 GO:0046122; P:purine deoxyribonucleoside metabolic process; IEA:Compara. 

Interpro

 IPR002624; Deoxynucleoside_kinase.
 IPR027417; P-loop_NTPase. 

Pfam

 PF01712; dNK 

SMART

  

PROSITE

  

PRINTS