UniProt Accession

 SODF_ECOLI; P0AGD3; P09157 

Genbank Protein ID

 J03511; U00096; AP009048 

Genbank Nucleotide ID

 AAA24637.1; AAC74728.1; BAA15422.1 

Protein Name

 Superoxide dismutase [Fe] 

Protein Synonyms/Alias

  

Gene Name

 sodB 

Gene Synonyms/Alias

 b1656; JW1648 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
12	LPALPYAKDALAPHI	acetylation	[1, 2]
30	TIEYHYGKHHQTYVT	acetylation	[1, 2]
44	TNLNNLIKGTAFEGK	acetylation	[1, 2]
44	TNLNNLIKGTAFEGK	pupylation	[3]
51	KGTAFEGKSLEEIIR	acetylation	[1, 2, 4]
117	QFTDAAIKNFGSGWT	acetylation	[1, 2]
128	SGWTWLVKNSDGKLA	acetylation	[1, 2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [3] Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coli.
 Cerda-Maira FA, McAllister F, Bode NJ, Burns KE, Gygi SP, Darwin KH.
 EMBO Rep. 2011 Jul 8;12(8):863-70. [PMID: 21738222]
 [4] Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli.
 Zhang J, Sprung R, Pei J, Tan X, Kim S, Zhu H, Liu CF, Grishin NV, Zhao Y.
 Mol Cell Proteomics. 2009 Feb;8(2):215-25. [PMID: 18723842] 

Functional Description

 Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. 

Sequence Annotation

 METAL 27 27 Iron.
 METAL 74 74 Iron.
 METAL 157 157 Iron.
 METAL 161 161 Iron.
 MOD_RES 51 51 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Iron; Metal-binding; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 193 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0005506; F:iron ion binding; IDA:EcoCyc.
 GO:0004784; F:superoxide dismutase activity; IDA:EcoCyc.
 GO:0019430; P:removal of superoxide radicals; IDA:EcoliWiki. 

Interpro

 IPR001189; Mn/Fe_SOD.
 IPR019833; Mn/Fe_SOD_BS.
 IPR019832; Mn/Fe_SOD_C.
 IPR019831; Mn/Fe_SOD_N. 

Pfam

 PF02777; Sod_Fe_C
 PF00081; Sod_Fe_N 

SMART

  

PROSITE

 PS00088; SOD_MN 

PRINTS

 PR01703; MNSODISMTASE.