CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005656
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gap junction beta-1 protein 
Protein Synonyms/Alias
 Connexin-32; Cx32 
Gene Name
 Gjb1 
Gene Synonyms/Alias
 Cxn-32 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
121PLHLEEVKRHKVHISubiquitination[1]
244HRLSPEYKQNEINKLubiquitination[1]
250YKQNEINKLLSEQDGubiquitination[1]
260SEQDGSLKDILRRSPubiquitination[1]
276TGAGLAEKSDRCSACubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. 
Sequence Annotation
 MOD_RES 258 258 Phosphoserine.
 MOD_RES 266 266 Phosphoserine.  
Keyword
 Cell junction; Cell membrane; Complete proteome; Gap junction; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 283 AA 
Protein Sequence
MNWTGLYTLL SGVNRHSTAI GRVWLSVIFI FRIMVLVVAA ESVWGDEKSS FICNTLQPGC 60
NSVCYDHFFP ISHVRLWSLQ LILVSTPALL VAMHVAHQQH IEKKMLRLEG HGDPLHLEEV 120
KRHKVHISGT LWWTYVISVV FRLLFEAVFM YVFYLLYPGY AMVRLVKCEA FPCPNTVDCF 180
VSRPTEKTVF TVFMLAASGI CIILNVAEVV YLIIRACARR AQRRSNPPSR KGSGFGHRLS 240
PEYKQNEINK LLSEQDGSLK DILRRSPGTG AGLAEKSDRC SAC 283 
Gene Ontology
 GO:0005922; C:connexon complex; IEA:InterPro.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005921; C:gap junction; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005243; F:gap junction channel activity; IEA:Compara.
 GO:0042803; F:protein homodimerization activity; IDA:MGI.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0051259; P:protein oligomerization; IEA:Compara.
 GO:0015868; P:purine ribonucleotide transport; IEA:Compara. 
Interpro
 IPR000500; Connexin.
 IPR002267; Connexin32.
 IPR019570; Connexin_CCC.
 IPR017990; Connexin_CS.
 IPR013092; Connexin_N. 
Pfam
 PF00029; Connexin
 PF10582; Connexin_CCC 
SMART
 SM00037; CNX
 SM01089; Connexin_CCC 
PROSITE
 PS00407; CONNEXINS_1
 PS00408; CONNEXINS_2 
PRINTS
 PR00206; CONNEXIN.
 PR01138; CONNEXINB1.