UniProt Accession

 HM13_MOUSE; Q9D8V0; A3KGS1; O19444; Q15K37; Q3TXP0; Q542R3; Q811Z6; Q8HWA9; Q8HWB5; Q9CQA4; Q9CSK9 

Genbank Protein ID

 AF515662; DQ168449; AJ345032; AF483214; AF483216; AK004690; AK007664; AK012600; AK019877; AK028109; AK049101; AK050664; AK080966; AK159176; AK169922; AL845162; AL845162; CH466551; CH466551; AF017785; BC034217 

Genbank Nucleotide ID

 AAN77098.1; ABA56162.1; CAC87793.1; AAM22075.1; AAM22077.1; BAB23476.1; BAB25172.1; BAB31897.1; BAC25752.1; BAC33543.1; BAC34369.1; BAC38098.1; BAE34875.1; BAE41461.1; CAM46159.1; CAM46160.1; EDL05980.1; EDL05981.1; AAB81863.1 

Protein Name

 Minor histocompatibility antigen H13 

Protein Synonyms/Alias

 Presenilin-like protein 3; Signal peptide peptidase 

Gene Name

 Hm13 

Gene Synonyms/Alias

 H13; Psl3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
61	SVRCARGKSSSDMPE	ubiquitination	[1]
241	KSFEAPIKLVFPQDL	ubiquitination	[1]
361	PAAETESKEESTEAS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (By similarity). May play a role in graft rejection. 

Sequence Annotation

 MOTIF 317 319 PAL.
 ACT_SITE 219 219 By similarity.
 ACT_SITE 265 265 By similarity.
 CARBOHYD 10 10 N-linked (GlcNAc...) (Potential).
 CARBOHYD 20 20 N-linked (GlcNAc...) (Potential).  

Keyword

 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Endoplasmic reticulum; Glycoprotein; Hydrolase; Membrane; Protease; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 378 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IDA:UniProtKB.
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0071458; C:integral to cytosolic side of endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0071556; C:integral to lumenal side of endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005791; C:rough endoplasmic reticulum; IEA:Compara.
 GO:0042500; F:aspartic endopeptidase activity, intramembrane cleaving; IEA:Compara.
 GO:0008233; F:peptidase activity; ISS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0033619; P:membrane protein proteolysis; ISS:UniProtKB. 

Interpro

 IPR006639; Peptidase_A22.
 IPR007369; Peptidase_A22B_SPP. 

Pfam

 PF04258; Peptidase_A22B 

SMART

 SM00730; PSN 

PROSITE

  

PRINTS