CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023644
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uncharacterized protein KIAA0947 
Protein Synonyms/Alias
  
Gene Name
 KIAA0947 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
521SASPAQEKEAAPGKSubiquitination[1]
745LPRSVFMKATKDGQCubiquitination[2]
765RIELTLNKPDFTSLIacetylation[3]
765RIELTLNKPDFTSLIubiquitination[1]
1218KASEIGEKYRKQPCEacetylation[1, 4, 5]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [5] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773
Functional Description
  
Sequence Annotation
 MOD_RES 255 255 Phosphoserine.
 MOD_RES 958 958 Phosphoserine.
 MOD_RES 1218 1218 N6-acetyllysine.
 MOD_RES 1588 1588 Phosphoserine.
 MOD_RES 1642 1642 Phosphothreonine.
 MOD_RES 1692 1692 Phosphoserine.
 MOD_RES 1697 1697 Phosphoserine.
 MOD_RES 1699 1699 Phosphoserine.
 MOD_RES 1701 1701 Phosphoserine.
 MOD_RES 1854 1854 Phosphoserine.
 MOD_RES 1903 1903 Phosphoserine.  
Keyword
 Acetylation; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2266 AA 
Protein Sequence
MMPGETHSAA PGTAADLSRC QGCASLQQNL NEYVEALITL KQKIINTDNL LTEYQKKCDE 60
LQFARRENSN LHHQVEEMLQ KISPLQKCQE ELGSLKAELE EKKSSLKLYQ DTHQEYARVK 120
EECLKSDAQK KKLEAKVKKL QEAAVKQTQD FKQLRNEKKI LEKEFKKTQE RLDEFSKQKN 180
EKELRHIGTQ ISSDSYGSID KRKVKLLLKE LWLCVNTTHR LPGEGSRCVP EKPAKAITSS 240
RVPGEDGTLP PTQGSPLRTS NVQTCLTKLS MEIKEDFLCQ NVEKQSSSGT NCSSDHVFNE 300
NGNLEVLVQS HRDGGSTEFV DHDHFFDEDL QAAIDFFKLP PPLLSPVPSP PPMSSPHPGS 360
LPSSFAPETY FGEYTDSSDN DSVQLRNSAE CVSEDDTTES QNYFGSLRKN KGSGTWEEKP 420
KSHEAIQALN TWEVNKVTTS GLETFTATLR ESSATHSLVG EKHWTTASRS MSDRKRDILH 480
ETKTQMEVRE MDKSVQTEKT IHKLTRGLCI ERLSASPAQE KEAAPGKSEL CSSPLGKRPL 540
NELMESEGKT VLSKMMGSPK SEFTKWTRIN EITSEPDRIT VSGHFHRLSR ELEKEKEDTQ 600
GFTLGESPES EDDDSGDGMD VAGLDIETSF SSSSTLVALS VGSNPQSSSG LDCGNDTDIT 660
TKVFSTEPHH SEHKLQTKTL NTLHLQSEPP ECSIGGNNLE NSLCALSPEL GASNFNDQKS 720
SGIEYTKVVK GLTKIHSLPR SVFMKATKDG QCESQDPRIE LTLNKPDFTS LIGSQAALIK 780
SGLGFVKSTS WHHSDLLRKG GEESLRAKSE HEQKTSHQLQ KAMPFLQNRG PTPKPDLLRE 840
NNNPVEFKTT ASVLPNQVSV ITKQTRPEKV QSAKLEHLRP HRVEPTLVTE NSGNKTGMST 900
VAKCDGERDD TTQNITEVAA VKSISPEVSA SRRKLDFNSP GGSSPVENSD CSTNSRLSFS 960
PENILIQNQD IVREAAVQGD GQKQRQPQAT DLDSSGTHGS EMLPATEVTV SGGFSVEETS 1020
CGDTGRSGGE ALAVANDSTS TPQNANGLWK LKSTTPGGAL PECFGTTDTT FSSAFCRKHG 1080
ETQDTSQSSL PGTLHCYTGI REGGDDTEVE SEAFSCSEGS EQQDAPDDSQ KNLGDTDAAV 1140
AEVRPSLEVG YLTSALQDFN ISTFSELDRL STSEVVMFLE SCQLGDYSSG DSVSECSSKG 1200
TLSKEMNKEL KASEIGEKYR KQPCEEETLG TCEEWIESEE DDYSLKNTSQ LTQCSLETLS 1260
EVLTKIRQEL QTNSEDCNGK DTGSLLLLNV NNNMTTENLK EKSPFRETTG SSSHASEPTP 1320
QAAALDTEGS SPISGMPQNE NPQSRPEARS DAGRQTDGGE EDLPEPVEPS ALCSDSVMEP 1380
SIEQSSNCEA ETTFQCQIAT VTSEVINVLI NKDQNLVIEK GDNWTIISGV AVLPHVDQVT 1440
LCDIPGDIPI SQDQGELEAG CIPVTSAEKS PEASHTGPAF QEAPCGNNLS CPQEDVSSSG 1500
QSTNFDKSRL RNRPVKPSIW ISSQIYDQNF ETQIVASDHT YYNSKLEPSG KNKNRSKISN 1560
KDQSNKPVKT SASSRVETHQ SEVAQSFSGE KANTKTQRSQ TQTILANADT STPTDCSPDT 1620
LSKIRQEVGP PLPPLLAPLI ATPPRTSQPL SPLISSSSPS SPASPVGQVS PFRETPVPPA 1680
MSPWPEDPRR ASPPDPSPSP SAASASERVV PSPLQFCAAT PKHALPVPGR LPPCASGHAA 1740
VGGPQENSVK ILDTMYPELS ARARTLNILK GNIQLTRGPP ADCKNLPGPA SAMIGFKTIT 1800
SAATAFVKTG SSSGGDCNQD KSRDLGTQQD SSGKRTLSTS TLRSAKRLRL DTGSPEPETR 1860
GVTAEGIHKN LPGNLPPAEV ATTNEERSCS SPAVSAVSQL PLSPKETVES HDKAIANALK 1920
KIAEFSFDLL PVIRSHVYVG NISKKPVMRD QEKEVVYEFS TTKKHLAECL LHSILSELKI 1980
QKISMDHNYI HALCRVYVGI CRQLGDLERA RLFCYSLLKE DFPESEKLTL FIANMWHDIF 2040
LSQSVINKAM QLVARQRAKG EVLNCLRAFL NWEKNAPVDV GFMVSKLLLT IQLCPKTEFQ 2100
PSEKFGEDLS DNTWEYIFAI DLLCCHQKWI WTHDNIISKE LWPVMDKWIK YRKGHANIAY 2160
TPDIIIASIL RLIGRLGQLG LKEGFPSAVK NISSVIGMFI QHAHDEDIPW GIQLAAVYAL 2220
CDLSPSNPAE ISKILEAWRR EASKSVPSAI VSCLEEVSAL STEELG 2266 
Gene Ontology
  
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS