| Tag | Content |
|---|
| CPLM ID | CPLM-012810 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Inverted formin-2 |
Protein Synonyms/Alias | HBEBP2-binding protein C |
Gene Name | INF2 |
Gene Synonyms/Alias | C14orf151; C14orf173 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 612 | LFSFPAAKPKEPTMV | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Severs actin filaments and accelerates their polymerization and depolymerization (By similarity). |
Sequence Annotation | DOMAIN 1 330 GBD/FH3.
DOMAIN 554 946 FH2.
DOMAIN 974 989 WH2.
MOD_RES 1147 1147 Phosphoserine.
MOD_RES 1149 1149 Phosphoserine.
MOD_RES 1179 1179 Phosphothreonine.
MOD_RES 1192 1192 Phosphoserine.
MOD_RES 1206 1206 Phosphothreonine. |
Keyword | Actin-binding; Alternative splicing; Charcot-Marie-Tooth disease; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Neuropathy; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1249 AA |
Protein Sequence | MSVKEGAQRK WAALKEKLGP QDSDPTEANL ESADPELCIR LLQMPSVVNY SGLRKRLEGS 60
DGGWMVQFLE QSGLDLLLEA LARLSGRGVA RISDALLQLT CVSCVRAVMN SRQGIEYILS 120
NQGYVRQLSQ ALDTSNVMVK KQVFELLAAL CIYSPEGHVL TLDALDHYKT VCSQQYRFSI 180
VMNELSGSDN VPYVVTLLSV INAVILGPED LRARTQLRNE FIGLQLLDVL ARLRDLEDAD 240
LLIQLEAFEE AKAEDEEELL RVSGGVDMSS HQEVFASLFH KVSCSPVSAQ LLSVLQGLLH 300
LEPTLRSSQL LWEALESLVN RAVLLASDAQ ECTLEEVVER LLSVKGRPRP SPLVKAHKSV 360
QANLDQSQRG SSPQNTTTPK PSVEGQQPAA AAACEPVDHA QSESILKVSQ PRALEQQAST 420
PPPPPPPPLL PGSSAEPPPP PPPPPLPSVG AKALPTAPPP PPLPGLGAMA PPAPPLPPPL 480
PGSCEFLPPP PPPLPGLGCP PPPPPLLPGM GWGPPPPPPP LLPCTCSPPV AGGMEEVIVA 540
QVDHGLGSAW VPSHRRVNPP TLRMKKLNWQ KLPSNVAREH NSMWASLSSP DAEAVEPDFS 600
SIERLFSFPA AKPKEPTMVA PRARKEPKEI TFLDAKKSLN LNIFLKQFKC SNEEVAAMIR 660
AGDTTKFDVE VLKQLLKLLP EKHEIENLRA FTEERAKLAS ADHFYLLLLA IPCYQLRIEC 720
MLLCEGAAAV LDMVRPKAQL VLAACESLLT SRQLPIFCQL ILRIGNFLNY GSHTGDADGF 780
KISTLLKLTE TKSQQNRVTL LHHVLEEAEK SHPDLLQLPR DLEQPSQAAG INLEIIRSEA 840
SSNLKKLLET ERKVSASVAE VQEQYTERLQ ASISAFRALD ELFEAIEQKQ RELADYLCED 900
AQQLSLEDTF STMKAFRDLF LRALKENKDR KEQAAKAERR KQQLAEEEAR RPRGEDGKPV 960
RKGPGKQEEV CVIDALLADI RKGFQLRKTA RGRGDTDGGS KAASMDPPRA TEPVATSNPA 1020
GDPVGSTRCP ASEPGLDATT ASESRGWDLV DAVTPGPQPT LEQLEEGGPR PLERRSSWYV 1080
DASDVLTTED PQCPQPLEGA WPVTLGDAQA LKPLKFSSNQ PPAAGSSRQD AKDPTSLLGV 1140
LQAEADSTSE GLEDAVHSRG ARPPAAGPGG DEDEDEEDTA PESALDTSLD KSFSEDAVTD 1200
SSGSGTLPRA RGRASKGTGK RRKKRPSRSQ EGLRPRPKAK 1240 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IDA:HPA. GO:0005634; C:nucleus; IDA:HPA. GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB. GO:0030036; P:actin cytoskeleton organization; IEA:InterPro. GO:0090140; P:regulation of mitochondrial fission; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |