CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039823
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Receptor tyrosine-protein kinase erbB-2 
Protein Synonyms/Alias
  
Gene Name
 ERBB2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
120RSLTEILKGGVLIQRubiquitination[1]
145LWKDIFHKNNQLALTubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 603 AA 
Protein Sequence
MKLRLPASPE THLDMLRHLY QGCQVVQGNL ELTYLPTNAS LSFLQDIQEV QGYVLIAHNQ 60
VRQVPLQRLR IVRGTQLFED NYALAVLDNG DPLNNTTPVT GASPGGLREL QLRSLTEILK 120
GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA LTLIDTNRSR ACHPCSPMCK GSRCWGESSE 180
DCQSLTRTVC AGGCARCKGP LPTDCCHEQC AAGCTGPKHS DCLACLHFNH SGICELHCPA 240
LVTYNTDTFE SMPNPEGRYT FGASCVTACP YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR 300
CEKCSKPCAR VCYGLGMEHL REVRAVTSAN IQEFAGCKKI FGSLAFLPES FDGDPASNTA 360
PLQPEQLQVF ETLEEITGYL YISAWPDSLP DLSVFQNLQV IRGRILHNGA YSLTLQGLGI 420
SWLGLRSLRE LGSGLALIHH NTHLCFVHTV PWDQLFRNPH QALLHTANRP EDECVGEGLA 480
CHQLCARGHC WGPGPTQCVN CSQFLRGQEC VEECRVLQGL PREYVNARHC LPCHPECQPQ 540
NGSVTCFGPE ADQCVACAHY KDPPFCVARC PSGVKPDLSY MPIWKFPDEE GACQPCPINC 600
THS 603 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0008045; P:motor neuron axon guidance; IEA:Compara.
 GO:0042552; P:myelination; IEA:Compara.
 GO:0033088; P:negative regulation of immature T cell proliferation in thymus; IEA:Compara.
 GO:0007528; P:neuromuscular junction development; IEA:Compara.
 GO:0007422; P:peripheral nervous system development; IEA:Compara.
 GO:0001934; P:positive regulation of protein phosphorylation; IEA:Compara.
 GO:0032321; P:positive regulation of Rho GTPase activity; IEA:Compara.
 GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro. 
Interpro
 IPR000494; EGF_rcpt_L.
 IPR006211; Furin-like_Cys-rich_dom.
 IPR006212; Furin_repeat.
 IPR009030; Growth_fac_rcpt_N_dom. 
Pfam
 PF00757; Furin-like
 PF01030; Recep_L_domain 
SMART
 SM00261; FU 
PROSITE
  
PRINTS