Tag | Content |
---|
CPLM ID | CPLM-022689 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Vacuolar protein sorting-associated protein 29 |
Protein Synonyms/Alias | Vesicle protein sorting 29 |
Gene Name | Vps29 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
---|
50 | KESYDYLKTLAGDVH | ubiquitination | [1] | 73 | NLNYPEQKVVTVGQF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p- nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro). |
Sequence Annotation | METAL 8 8 Zinc 1. METAL 10 10 Zinc 1. METAL 39 39 Zinc 1. METAL 39 39 Zinc 2. METAL 62 62 Zinc 2. METAL 86 86 Zinc 2. METAL 115 115 Zinc 2. METAL 117 117 Zinc 1. MOD_RES 50 50 N6-acetyllysine (By similarity). |
Keyword | 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Endosome; Hydrolase; Membrane; Metal-binding; Protein transport; Reference proteome; Transport; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 182 AA |
Protein Sequence | MLVLVLGDLH IPHRCNSLPA KFKKLLVPGK IQHILCTGNL CTKESYDYLK TLAGDVHIVR 60 GDFDENLNYP EQKVVTVGQF KIGLIHGHQV IPWGDMASLA LLQRQFDVDI LISGHTHKFE 120 AFEHENKFYI NPGSATGAYN ALETNIIPSF VLMDIQASTV VTYVYQLIGD DVKVERIEYK 180 KS 182 |
Gene Ontology | GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004647; F:phosphoserine phosphatase activity; IEA:EC. GO:0006896; P:Golgi to vacuole transport; ISS:MGI. GO:0015031; P:protein transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |