CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005528
UniProt Accession
Genbank Protein ID
 X15551 
Genbank Nucleotide ID
Protein Name
 Beta-2-glycoprotein 1 
Protein Synonyms/Alias
 Apolipoprotein H; Apo-H; Beta-2-glycoprotein I; B2GPI; Beta(2)GPI 
Gene Name
 Apoh 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
106IPKFAALKEYKTSVGacetylation[1]
239VKIQDQFKNGMMHGDacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. 
Sequence Annotation
 DOMAIN 20 32 Sushi 1; incomplete.
 DOMAIN 34 91 Sushi 2.
 DOMAIN 92 154 Sushi 3.
 DOMAIN 155 214 Sushi 4.
 REGION 215 297 Sushi-like.
 CARBOHYD 69 69 N-linked (GlcNAc...) (Potential).
 CARBOHYD 114 114 N-linked (GlcNAc...) (Potential).
 CARBOHYD 135 135 N-linked (GlcNAc...) (Potential).
 CARBOHYD 145 145 N-linked (GlcNAc...) (Potential).
 CARBOHYD 205 205 N-linked (GlcNAc...) (Potential).
 DISULFID 36 76 By similarity.
 DISULFID 62 89 By similarity.
 DISULFID 94 140 By similarity.
 DISULFID 126 152 By similarity.
 DISULFID 157 200 By similarity.
 DISULFID 186 212 By similarity.
 DISULFID 216 267 By similarity.
 DISULFID 252 277 By similarity.
 DISULFID 259 297 By similarity.  
Keyword
 Complete proteome; Disulfide bond; Glycoprotein; Heparin-binding; Reference proteome; Repeat; Secreted; Signal; Sushi. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 297 AA 
Protein Sequence
MISPALIFFS AFLCHVAIAG RRMWPINTLK CTPRVCPFAG ILENGVVRYT TFEYPNTIGF 60
ACNPGYYLNG TSSSKCTEEG KWSPELPVCA RITCPPPPIP KFAALKEYKT SVGNSSFYQD 120
TVVFKCLPHF AMFGNDTVTC TAHGNWTQLP ECREVKCPFP SRPDNGFVNY PAKPVLSYKD 180
KAVFGCHETY KLDGPEEVEC TKTGNWSALP SCKASCKLSV KKATVLYQGQ RVKIQDQFKN 240
GMMHGDKVHF YCKNKEKKCS YTEEAQCIDG TIEIPKCFKE HSSLAFWKTD ASDVTPC 297 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
 GO:0008289; F:lipid binding; IDA:RGD.
 GO:0007596; P:blood coagulation; IMP:RGD.
 GO:0031100; P:organ regeneration; IMP:RGD.
 GO:0034197; P:triglyceride transport; IDA:BHF-UCL. 
Interpro
 IPR015104; Sushi_2.
 IPR000436; Sushi_SCR_CCP. 
Pfam
 PF00084; Sushi
 PF09014; Sushi_2 
SMART
 SM00032; CCP 
PROSITE
 PS50923; SUSHI 
PRINTS