UniProt Accession

 RGS19_HUMAN; P49795; A8K216; E1P5G9; Q53XN0; Q8TD60 

Genbank Protein ID

 X91809; AF493939; AY585188; BT009804; AK290081; AL590548; CH471077; CH471077; BC001318; BC054337; BC063010 

Genbank Nucleotide ID

 CAA62919.1; AAM12653.1; AAS94232.1; AAP88806.1; BAF82770.1; CAD11902.1; EAW75166.1; EAW75167.1; AAH01318.1; AAH54337.1; AAH63010.1 

Protein Name

 Regulator of G-protein signaling 19 

Protein Synonyms/Alias

 RGS19; G-alpha-interacting protein; GAIP 

Gene Name

 RGS19 

Gene Synonyms/Alias

 GAIP; GNAI3IP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
138	NQHVVDEKARLIYED	ubiquitination	[1, 2, 3]
153	YVSILSPKEVSLDSR	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. 

Sequence Annotation

 DOMAIN 90 206 RGS.
 REGION 207 217 Interaction with GIPC.
 MOD_RES 24 24 Phosphoserine (By similarity).
 MOD_RES 97 97 Phosphoserine.
 MOD_RES 151 151 Phosphoserine; by MAPK1 and MAPK3.  

Keyword

 3D-structure; Autophagy; Complete proteome; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome; Signal transduction inhibitor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0005903; C:brush border; IEA:Compara.
 GO:0030136; C:clathrin-coated vesicle; IEA:Compara.
 GO:0005794; C:Golgi apparatus; TAS:ProtInc.
 GO:0005886; C:plasma membrane; IBA:RefGenome.
 GO:0005096; F:GTPase activator activity; IBA:RefGenome.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW.
 GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.
 GO:0007264; P:small GTPase mediated signal transduction; TAS:ProtInc.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. 

Interpro

 IPR000342; Regulat_G_prot_signal.
 IPR024066; Regulat_G_prot_signal_dom1.
 IPR016137; Regulat_G_prot_signal_superfam. 

Pfam

 PF00615; RGS 

SMART

 SM00315; RGS 

PROSITE

 PS50132; RGS 

PRINTS

 PR01301; RGSPROTEIN.