CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018803
UniProt Accession
Genbank Protein ID
 X98330; AJ300340; AJ300341; AJ300342; AJ300343; AJ300347; AJ300349; AJ300351; AJ300353; AJ300355; AJ300364; AJ300363; AJ300362; AJ300361; AJ300360; AJ300359; AJ300358; AJ300357; AJ300356; AJ300373; AJ300372; AJ300371; AJ300370; AJ300369; AJ300368; AJ300367; AJ300366; AJ300365; AJ300382; AJ300381; AJ300380; AJ300379; AJ300378; AJ300377; AJ300376; AJ300375; AJ300374; AJ300399; AJ300398; AJ300397; AJ300396; AJ300395; AJ300394; AJ300393; AJ300392; AJ300391; AJ300416; AJ300415; AJ300414; AJ300413; AJ300412; AJ300411; AJ300410; AJ300409; AJ300408; AJ300433; AJ300432; AJ300431; AJ300430; AJ300429; AJ300428; AJ300427; AJ300426; AJ300425; AJ300444; AJ300443; AJ300442; AJ300441; AJ300440; AJ300439; AJ300438; AJ300437; AJ300436; AJ300435; AJ300434; AJ300424; AJ300423; AJ300422; AJ300421; AJ300420; AJ300419; AJ300418; AJ300417; AJ300407; AJ300406; AJ300405; AJ300404; AJ300403; AJ300402; AJ300401; AJ300400; AJ300390; AJ300389; AJ300388; AJ300387; AJ300386; AJ300385; AJ300384; AJ300383; AJ300354; AJ300352; AJ300350; AJ300348; AJ300346; AJ300345; AJ300344; AL365332; AL356773; AL359924; AL391809; AL442065; AL445473; AL513130; AL445473; AL356773; AL359924; AL365332; AL391809; AL442065; AL513130; AL356773; AL359924; AL365332; AL391809; AL442065; AL445473; AL513130; AL391809; AL356773; AL359924; AL365332; AL442065; AL445473; AL513130; AL442065; AL356773; AL359924; AL365332; AL391809; AL445473; AL513130; AL513130; AL356773; AL359924; AL365332; AL391809; AL442065; AL445473; AL359924; AL356773; AL365332; AL391809; AL442065; AL445473; AL513130; Y08218; X91869; AJ002511 
Genbank Nucleotide ID
 CAA66975.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAC18855.1; CAH71369.1; CAH71369.1; CAH71369.1; CAH71369.1; CAH71369.1; CAH71369.1; CAH71369.1; CAH71393.1; CAH71393.1; CAH71393.1; CAH71393.1; CAH71393.1; CAH71393.1; CAH71393.1; CAH73918.1; CAH73918.1; CAH73918.1; CAH73918.1; CAH73918.1; CAH73918.1; CAH73918.1; CAI14440.1; CAI14440.1; CAI14440.1; CAI14440.1; CAI14440.1; CAI14440.1; CAI14440.1; CAI15350.1; CAI15350.1; CAI15350.1; CAI15350.1; CAI15350.1; CAI15350.1; CAI15350.1; CAI15936.1; CAI15936.1; CAI15936.1; CAI15936.1; CAI15936.1; CAI15936.1; CAI15936.1; CAI22065.1; CAI22065.1; CAI22065.1; CAI22065.1; CAI22065.1; CAI22065.1; CAI22065.1; CAA69395.1; CAA62975.1; CAA05502.1 
Protein Name
 Ryanodine receptor 2 
Protein Synonyms/Alias
 RYR-2; RyR2; hRYR-2; Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Type 2 ryanodine receptor 
Gene Name
 RYR2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
390RMGSIQRKAIMHHEGubiquitination[1]
3712DDGEEEVKSFEEKEMubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. 
Sequence Annotation
 DOMAIN 110 165 MIR 1.
 DOMAIN 172 217 MIR 2.
 DOMAIN 225 280 MIR 3.
 DOMAIN 286 343 MIR 4.
 DOMAIN 351 408 MIR 5.
 DOMAIN 599 809 B30.2/SPRY 1.
 REPEAT 853 966 1.
 REPEAT 967 1080 2.
 DOMAIN 1025 1222 B30.2/SPRY 2.
 DOMAIN 1337 1562 B30.2/SPRY 3.
 REPEAT 2692 2810 3.
 REPEAT 2812 2925 4.
 REGION 853 2925 4 X approximate repeats.
 REGION 3581 3610 Interaction with CALM.
 MOD_RES 2031 2031 Phosphoserine; by PKA (By similarity).
 MOD_RES 2808 2808 Phosphoserine; by CaMK2D and PKA.
 MOD_RES 2814 2814 Phosphoserine; by CaMK2D.  
Keyword
 Alternative splicing; Calcium; Calcium channel; Calcium transport; Calmodulin-binding; Cardiomyopathy; Coiled coil; Complete proteome; Developmental protein; Disease mutation; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Sarcoplasmic reticulum; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4967 AA 
Protein Sequence
MADGGEGEDE IQFLRTDDEV VLQCTATIHK EQQKLCLAAE GFGNRLCFLE STSNSKNVPP 60
DLSICTFVLE QSLSVRALQE MLANTVEKSE GQVDVEKWKF MMKTAQGGGH RTLLYGHAIL 120
LRHSYSGMYL CCLSTSRSST DKLAFDVGLQ EDTTGEACWW TIHPASKQRS EGEKVRVGDD 180
LILVSVSSER YLHLSYGNGS LHVDAAFQQT LWSVAPISSG SEAAQGYLIG GDVLRLLHGH 240
MDECLTVPSG EHGEEQRRTV HYEGGAVSVH ARSLWRLETL RVAWSGSHIR WGQPFRLRHV 300
TTGKYLSLME DKNLLLMDKE KADVKSTAFT FRSSKEKLDV GVRKEVDGMG TSEIKYGDSV 360
CYIQHVDTGL WLTYQSVDVK SVRMGSIQRK AIMHHEGHMD DGISLSRSQH EESRTARVIR 420
STVFLFNRFI RGLDALSKKA KASTVDLPIE SVSLSLQDLI GYFHPPDEHL EHEDKQNRLR 480
ALKNRQNLFQ EEGMINLVLE CIDRLHVYSS AAHFADVAGR EAGESWKSIL NSLYELLAAL 540
IRGNRKNCAQ FSGSLDWLIS RLERLEASSG ILEVLHCVLV ESPEALNIIK EGHIKSIISL 600
LDKHGRNHKV LDVLCSLCVC HGVAVRSNQH LICDNLLPGR DLLLQTRLVN HVSSMRPNIF 660
LGVSEGSAQY KKWYYELMVD HTEPFVTAEA THLRVGWAST EGYSPYPGGG EEWGGNGVGD 720
DLFSYGFDGL HLWSGCIART VSSPNQHLLR TDDVISCCLD LSAPSISFRI NGQPVQGMFE 780
NFNIDGLFFP VVSFSAGIKV RFLLGGRHGE FKFLPPPGYA PCYEAVLPKE KLKVEHSREY 840
KQERTYTRDL LGPTVSLTQA AFTPIPVDTS QIVLPPHLER IREKLAENIH ELWVMNKIEL 900
GWQYGPVRDD NKRQHPCLVE FSKLPEQERN YNLQMSLETL KTLLALGCHV GISDEHAEDK 960
VKKMKLPKNY QLTSGYKPAP MDLSFIKLTP SQEAMVDKLA ENAHNVWARD RIRQGWTYGI 1020
QQDVKNRRNP RLVPYTLLDD RTKKSNKDSL REAVRTLLGY GYNLEAPDQD HAARAEVCSG 1080
TGERFRIFRA EKTYAVKAGR WYFEFETVTA GDMRVGWSRP GCQPDQELGS DERAFAFDGF 1140
KAQRWHQGNE HYGRSWQAGD VVGCMVDMNE HTMMFTLNGE ILLDDSGSEL AFKDFDVGDG 1200
FIPVCSLGVA QVGRMNFGKD VSTLKYFTIC GLQEGYEPFA VNTNRDITMW LSKRLPQFLQ 1260
VPSNHEHIEV TRIDGTIDSS PCLKVTQKSF GSQNSNTDIM FYRLSMPIEC AEVFSKTVAG 1320
GLPGAGLFGP KNDLEDYDAD SDFEVLMKTA HGHLVPDRVD KDKEATKPEF NNHKDYAQEK 1380
PSRLKQRFLL RRTKPDYSTS HSARLTEDVL ADDRDDYDFL MQTSTYYYSV RIFPGQEPAN 1440
VWVGWITSDF HQYDTGFDLD RVRTVTVTLG DEKGKVHESI KRSNCYMVCA GESMSPGQGR 1500
NNNGLEIGCV VDAASGLLTF IANGKELSTY YQVEPSTKLF PAVFAQATSP NVFQFELGRI 1560
KNVMPLSAGL FKSEHKNPVP QCPPRLHVQF LSHVLWSRMP NQFLKVDVSR ISERQGWLVQ 1620
CLDPLQFMSL HIPEENRSVD ILELTEQEEL LKFHYHTLRL YSAVCALGNH RVAHALCSHV 1680
DEPQLLYAIE NKYMPGLLRA GYYDLLIDIH LSSYATARLM MNNEYIVPMT EETKSITLFP 1740
DENKKHGLPG IGLSTSLRPR MQFSSPSFVS ISNECYQYSP EFPLDILKSK TIQMLTEAVK 1800
EGSLHARDPV GGTTEFLFVP LIKLFYTLLI MGIFHNEDLK HILQLIEPSV FKEAATPEEE 1860
SDTLEKELSV DDAKLQGAGE EEAKGGKRPK EGLLQMKLPE PVKLQMCLLL QYLCDCQVRH 1920
RIEAIVAFSD DFVAKLQDNQ RFRYNEVMQA LNMSAALTAR KTKEFRSPPQ EQINMLLNFK 1980
DDKSECPCPE EIRDQLLDFH EDLMTHCGIE LDEDGSLDGN SDLTIRGRLL SLVEKVTYLK 2040
KKQAEKPVES DSKKSSTLQQ LISETMVRWA QESVIEDPEL VRAMFVLLHR QYDGIGGLVR 2100
ALPKTYTING VSVEDTINLL ASLGQIRSLL SVRMGKEEEK LMIRGLGDIM NNKVFYQHPN 2160
LMRALGMHET VMEVMVNVLG GGESKEITFP KMVANCCRFL CYFCRISRQN QKAMFDHLSY 2220
LLENSSVGLA SPAMRGSTPL DVAAASVMDN NELALALREP DLEKVVRYLA GCGLQSCQML 2280
VSKGYPDIGW NPVEGERYLD FLRFAVFCNG ESVEENANVV VRLLIRRPEC FGPALRGEGG 2340
NGLLAAMEEA IKIAEDPSRD GPSPNSGSSK TLDTEEEEDD TIHMGNAIMT FYSALIDLLG 2400
RCAPEMHLIH AGKGEAIRIR SILRSLIPLG DLVGVISIAF QMPTIAKDGN VVEPDMSAGF 2460
CPDHKAAMVL FLDRVYGIEV QDFLLHLLEV GFLPDLRAAA SLDTAALSAT DMALALNRYL 2520
CTAVLPLLTR CAPLFAGTEH HASLIDSLLH TVYRLSKGCS LTKAQRDSIE VCLLSICGQL 2580
RPSMMQHLLR RLVFDVPLLN EHAKMPLKLL TNHYERCWKY YCLPGGWGNF GAASEEELHL 2640
SRKLFWGIFD ALSQKKYEQE LFKLALPCLS AVAGALPPDY MESNYVSMME KQSSMDSEGN 2700
FNPQPVDTSN ITIPEKLEYF INKYAEHSHD KWSMDKLANG WIYGEIYSDS SKVQPLMKPY 2760
KLLSEKEKEI YRWPIKESLK TMLAWGWRIE RTREGDSMAL YNRTRRISQT SQVSVDAAHG 2820
YSPRAIDMSN VTLSRDLHAM AEMMAENYHN IWAKKKKMEL ESKGGGNHPL LVPYDTLTAK 2880
EKAKDREKAQ DILKFLQING YAVSRGFKDL ELDTPSIEKR FAYSFLQQLI RYVDEAHQYI 2940
LEFDGGSRGK GEHFPYEQEI KFFAKVVLPL IDQYFKNHRL YFLSAASRPL CSGGHASNKE 3000
KEMVTSLFCK LGVLVRHRIS LFGNDATSIV NCLHILGQTL DARTVMKTGL ESVKSALRAF 3060
LDNAAEDLEK TMENLKQGQF THTRNQPKGV TQIINYTTVA LLPMLSSLFE HIGQHQFGED 3120
LILEDVQVSC YRILTSLYAL GTSKSIYVER QRSALGECLA AFAGAFPVAF LETHLDKHNI 3180
YSIYNTKSSR ERAALSLPTN VEDVCPNIPS LEKLMEEIVE LAESGIRYTQ MPHVMEVILP 3240
MLCSYMSRWW EHGPENNPER AEMCCTALNS EHMNTLLGNI LKIIYNNLGI DEGAWMKRLA 3300
VFSQPIINKV KPQLLKTHFL PLMEKLKKKA ATVVSEEDHL KAEARGDMSE AELLILDEFT 3360
TLARDLYAFY PLLIRFVDYN RAKWLKEPNP EAEELFRMVA EVFIYWSKSH NFKREEQNFV 3420
VQNEINNMSF LITDTKSKMS KAAVSDQERK KMKRKGDRYS MQTSLIVAAL KRLLPIGLNI 3480
CAPGDQELIA LAKNRFSLKD TEDEVRDIIR SNIHLQGKLE DPAIRWQMAL YKDLPNRTDD 3540
TSDPEKTVER VLDIANVLFH LEQKSKRVGR RHYCLVEHPQ RSKKAVWHKL LSKQRKRAVV 3600
ACFRMAPLYN LPRHRAVNLF LQGYEKSWIE TEEHYFEDKL IEDLAKPGAE PPEEDEGTKR 3660
VDPLHQLILL FSRTALTEKC KLEEDFLYMA YADIMAKSCH DEEDDDGEEE VKSFEEKEME 3720
KQKLLYQQAR LHDRGAAEMV LQTISASKGE TGPMVAATLK LGIAILNGGN STVQQKMLDY 3780
LKEKKDVGFF QSLAGLMQSC SVLDLNAFER QNKAEGLGMV TEEGSGEKVL QDDEFTCDLF 3840
RFLQLLCEGH NSDFQNYLRT QTGNNTTVNI IISTVDYLLR VQESISDFYW YYSGKDVIDE 3900
QGQRNFSKAI QVAKQVFNTL TEYIQGPCTG NQQSLAHSRL WDAVVGFLHV FAHMQMKLSQ 3960
DSSQIELLKE LMDLQKDMVV MLLSMLEGNV VNGTIGKQMV DMLVESSNNV EMILKFFDMF 4020
LKLKDLTSSD TFKEYDPDGK GVISKRDFHK AMESHKHYTQ SETEFLLSCA ETDENETLDY 4080
EEFVKRFHEP AKDIGFNVAV LLTNLSEHMP NDTRLQTFLE LAESVLNYFQ PFLGRIEIMG 4140
SAKRIERVYF EISESSRTQW EKPQVKESKR QFIFDVVNEG GEKEKMELFV NFCEDTIFEM 4200
QLAAQISESD LNERSANKEE SEKERPEEQG PRMAFFSILT VRSALFALRY NILTLMRMLS 4260
LKSLKKQMKK VKKMTVKDMV TAFFSSYWSI FMTLLHFVAS VFRGFFRIIC SLLLGGSLVE 4320
GAKKIKVAEL LANMPDPTQD EVRGDGEEGE RKPLEAALPS EDLTDLKELT EESDLLSDIF 4380
GLDLKREGGQ YKLIPHNPNA GLSDLMSNPV PMPEVQEKFQ EQKAKEEEKE EKEETKSEPE 4440
KAEGEDGEKE EKAKEDKGKQ KLRQLHTHRY GEPEVPESAF WKKIIAYQQK LLNYFARNFY 4500
NMRMLALFVA FAINFILLFY KVSTSSVVEG KELPTRSSSE NAKVTSLDSS SHRIIAVHYV 4560
LEESSGYMEP TLRILAILHT VISFFCIIGY YCLKVPLVIF KREKEVARKL EFDGLYITEQ 4620
PSEDDIKGQW DRLVINTQSF PNNYWDKFVK RKVMDKYGEF YGRDRISELL GMDKAALDFS 4680
DAREKKKPKK DSSLSAVLNS IDVKYQMWKL GVVFTDNSFL YLAWYMTMSV LGHYNNFFFA 4740
AHLLDIAMGF KTLRTILSSV THNGKQLVLT VGLLAVVVYL YTVVAFNFFR KFYNKSEDGD 4800
TPDMKCDDML TCYMFHMYVG VRAGGGIGDE IEDPAGDEYE IYRIIFDITF FFFVIVILLA 4860
IIQGLIIDAF GELRDQQEQV KEDMETKCFI CGIGNDYFDT VPHGFETHTL QEHNLANYLF 4920
FLMYLINKDE TEHTGQESYV WKMYQERCWE FFPAGDCFRK QYEDQLN 4967 
Gene Ontology
 GO:0034704; C:calcium channel complex; IDA:BHF-UCL.
 GO:0014701; C:junctional sarcoplasmic reticulum membrane; TAS:BHF-UCL.
 GO:0005886; C:plasma membrane; ISS:BHF-UCL.
 GO:0030018; C:Z disc; ISS:BHF-UCL.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0048763; F:calcium-induced calcium release activity; IDA:BHF-UCL.
 GO:0005516; F:calmodulin binding; IMP:BHF-UCL.
 GO:0044325; F:ion channel binding; ISS:BHF-UCL.
 GO:0034236; F:protein kinase A catalytic subunit binding; IDA:BHF-UCL.
 GO:0034237; F:protein kinase A regulatory subunit binding; IDA:BHF-UCL.
 GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IDA:BHF-UCL.
 GO:0043924; F:suramin binding; IMP:BHF-UCL.
 GO:0030509; P:BMP signaling pathway; IEA:Compara.
 GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IDA:BHF-UCL.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0060048; P:cardiac muscle contraction; IMP:BHF-UCL.
 GO:0003300; P:cardiac muscle hypertrophy; ISS:BHF-UCL.
 GO:0086064; P:cell communication by electrical coupling involved in cardiac conduction; IC:BHF-UCL.
 GO:0071313; P:cellular response to caffeine; ISS:UniProtKB.
 GO:0005513; P:detection of calcium ion; IDA:BHF-UCL.
 GO:0003143; P:embryonic heart tube morphogenesis; ISS:UniProtKB.
 GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IDA:BHF-UCL.
 GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; ISS:BHF-UCL.
 GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IDA:BHF-UCL.
 GO:0010460; P:positive regulation of heart rate; ISS:BHF-UCL.
 GO:0086094; P:positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction; ISS:BHF-UCL.
 GO:0051284; P:positive regulation of sequestering of calcium ion; IDA:BHF-UCL.
 GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; ISS:BHF-UCL.
 GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; ISS:BHF-UCL.
 GO:0086005; P:regulation of ventricular cardiac muscle cell action potential; ISS:BHF-UCL.
 GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IMP:BHF-UCL.
 GO:0001666; P:response to hypoxia; ISS:BHF-UCL.
 GO:0051775; P:response to redox state; IDA:BHF-UCL.
 GO:0097050; P:type B pancreatic cell apoptotic process; IMP:BHF-UCL. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR000699; Ca-rel_channel.
 IPR008985; ConA-like_lec_gl_sf.
 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom.
 IPR014821; Ins145_P3_rcpt.
 IPR005821; Ion_trans_dom.
 IPR016093; MIR_motif.
 IPR013662; RIH_assoc-dom.
 IPR013333; Ryan_recept.
 IPR003032; Ryanodine_rcpt.
 IPR015925; Ryanodine_recept-rel.
 IPR009460; Ryanrecept_TM4-6.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt. 
Pfam
 PF08709; Ins145_P3_rec
 PF00520; Ion_trans
 PF02815; MIR
 PF08454; RIH_assoc
 PF06459; RR_TM4-6
 PF01365; RYDR_ITPR
 PF02026; RyR
 PF00622; SPRY 
SMART
 SM00054; EFh
 SM00472; MIR
 SM00449; SPRY 
PROSITE
 PS50188; B302_SPRY
 PS50919; MIR 
PRINTS
 PR00795; RYANODINER.