Tag | Content |
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CPLM ID | CPLM-024352 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase UBR4 |
Protein Synonyms/Alias | N-recognin-4; Zinc finger UBR1-type protein 1; p600 |
Gene Name | Ubr4 |
Gene Synonyms/Alias | Kiaa0462; Zubr1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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187 | VSPELRQKEVQMNFL | ubiquitination | [1] | 634 | NKQASGEKGNILASR | ubiquitination | [1] | 1149 | AAETDPHKSSEITKN | ubiquitination | [1] | 1573 | CKKYLSQKNVVEKLN | ubiquitination | [1] | 4047 | MCLRILQKLIKPPAP | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. |
Sequence Annotation | ZN_FING 1655 1728 UBR-type. MOD_RES 178 178 Phosphoserine. MOD_RES 181 181 Phosphoserine. MOD_RES 365 365 Phosphoserine. MOD_RES 1083 1083 N6-acetyllysine (By similarity). MOD_RES 1401 1401 Phosphoserine (By similarity). MOD_RES 2712 2712 Phosphothreonine. MOD_RES 2716 2716 Phosphoserine. MOD_RES 2719 2719 Phosphoserine. MOD_RES 2721 2721 Phosphothreonine. |
Keyword | Acetylation; Alternative splicing; Calmodulin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Ligase; Membrane; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 5180 AA |
Protein Sequence | MATSGGEEAA AAAPAPGAPA TGQDTTPGWE VAVRPLLSAS YSAFEMKELP QLVASVIESE 60 SEILHHEKQY EPFYSSFVAL STHYITTVCS LIPRNQLQSV AAACKVLIEF SLLRLENPDE 120 ACAVSQKHLI LLIKGLCTGC SRLDRTEIIT FTAMMKSAKL PQTVKTLSDV EDQKELASPV 180 SPELRQKEVQ MNFLNQLTSV FNPRTVPSPP ISPQALVEGE NDEQSSPDQV SAAKTKSVFI 240 AQNVASLQEL GGSEKLLRVC LNLPYFLRYI NRFQDAVVAN SFFIMPATVA DATAVRNGFH 300 SLVIDVTMAL DTLSLPVLEP LNPSRLQDVT VLSLSCLYAG VSVATCMAIL HVGSAQQVRT 360 GSTSSKEDDY ESDAATIVQK CLEIYDMIGQ AISSSRRAGG EHFQNFQLLG AWCLLNSLFL 420 ILNLSPTALA DKGKEKDPLA ALRVRDILSR TKEGVGSPKL GPGKGHQGFG VLSVILANHA 480 IKLLASLFQD LQVEALHKGW ETDGPPAVLS IMAQSTSTQR IQRLIDSVPL TNLLLTLLST 540 SYRKACVLQR QRKGSMSSDA SASTDSNTYY EDDFSSTEED SSQDDDSEPI LGQWFEETIS 600 PSKEKAAPPP PPPPPPLESS PRVKSPNKQA SGEKGNILAS RKDPELFSGL ASNILNFITT 660 SMLNSRNSFI RSYLSASLSE HHMATLASII KEVDKDGLKG SSDEDFAAAL YHFNHSLVTS 720 DLQSPNLQNT LLQQLGVAPF SEGPWPLYIH PQGLSVLSRL LLIWQHKAGA QGDPDVPECL 780 KVWDRFLTTM KQNALQGVVP SETEDLNVEH LQLLLLIFHS FSEKGRRAIL TMLVQSIQEL 840 SVNMEVQMRT APLILARLLL IFDYLLHQYS KAPVYLFEQV QHNLLSPPFG WASGSQDSSS 900 RRANTPLYHG FKEVEENWSK HFSSDAAPQP RFYCVLSTEA SEEDLNRLDS EACEVLFSKP 960 VKYDELYSSL TTLLAAGSQL DTTRRKEKKN VTALEACALQ YYFLILWRIL GILPPSKTYM 1020 NQLAMNSPEM SECDILHTLR WSSRLRISSY VSWIKDHLIK QGMKPEHAGS LIELAASKCS 1080 SVKYDVEIVE EYFARQISSF CSIDCTAVLQ LHEIPSLQSI YTLDAAVSKV QVSLDEHFSK 1140 MAAETDPHKS SEITKNLLPA TLQLIDTYAS FTRAYLLQNL NEEGSTEKPS QEKLHGFAAV 1200 LAIGSSRCKA NTLGPTLVQN LPSSVQSVCE SWNNINTNEF PNIGSWRNAF ANDTIPSESY 1260 ISAVQAAHLG TLCGQSLPLA ASLKHTLLSL VRLTGDLIVW SDEMNPAQVI RTLLPLLLES 1320 STESAAEISS NSLERILGPA ESDEFLARVY EKLITGCYNI LANHADPNSG LDESILEECL 1380 QYLEKQLESS QARKAMEEFF SDGGELVQIM MATANEDLSA KFCNRVLKFF TKLFQLTEKS 1440 PNPSLLHLCG SLAQLACVEP VRLQAWLTRM TTSPPKDSDQ LEVIQENRQL LQLLTTYIVR 1500 ENSQVGEGVC AVLLGTLTPM ATDMLANGDG TGFPELMVVM ATLASAGQGA GHLQLHNAAV 1560 DWLGRCKKYL SQKNVVEKLN ANVMHGKHVM VLECTCHIMS YLADVTNALS QSNGQGPSHL 1620 SVDGEERAIE VDSDWVEELA VEEEDSQAED SDEDSLCNKL CTFTITQKEF MNQHWYHCHT 1680 CKMVDGVGVC TVCAKVCHKD HEISYAKYGS FFCDCGAKED GSCLALVKRT PSSGMSSTMK 1740 ESAFQSEPRV SESLVRHAST SPADKAKVTI SDGKVTDEEK PKKSSLCRTV EGCREELQNQ 1800 ANFSFAPLVL DMLSFLMDAI QTNFQQASAV GSSSRAQQAL SELHTVDKGV EMTDQLMVPT 1860 LGSQEGAFEN VRMNYSGDQG QTIRQLISAH VLRRVAMCVL SSPHGRRQHL AVSHEKGKIT 1920 VLQLSALLKQ ADSSKRKLTL TRLASAPVPF TVLSLTGNPC KEDYLAVCGL KDCHVLTFSS 1980 SGSVSDHLVL HPQLATGNFI IKAVWLPGSQ TELAIVTADF VKIYDLSIDA LSPTFYFLLP 2040 SSKIRDVTFL FNEEGKNIIV IMSSAGYMYT QLMEEASSAQ QGPFYVTNVL EINHEDLKDS 2100 NSQVAGGGVS VYYSHVLQML FFSYSQGRSF AATVSRSTLE VLQLFPINIK SSNGGSKTSP 2160 ALCQWSEVMN HPGLVCCVQQ TTGVPLVVMV KPGTFLIQEI KTLPAKAKIQ DMVAIRHTAC 2220 NEQQRTTMIL LCEDGSLRIY MANVENTSYW LQPSLQPSSV ISIMKPVRKR KTATITARTS 2280 SQVTFPIDFF EHNQQLTDVE FGGNDLLQVY NAQQIKHRLN STGMYVANTK PGGFTIEISN 2340 NSSTMVMTGM RIQIGTQAIE RAPSYIEIFG RTMQLNLSRS RWFDFPFTRE EALQADRKLS 2400 LFIGASVDPA GVTMIDAVKI YGKTKEQFGW PDEPPEDFPS ASVSNICPPN LNQSNGTGES 2460 DSAAPATTSG TVLERLVVSS LEALESCFAV GPIIEKERNK HAAQELATLL LSLPAPASVQ 2520 QQSKSLLASL HSSRSAYHSH KDQALLSKAV QCLNTSSKEG KDLDPEVFQR LVITARSIAV 2580 TRPNNLVHFT ESKLPQMETD CFSPRCACWN LGIVGILIGA PLETPSAEGA DEGKEPQKQE 2640 GDGCSFITQL VNHFWKLHAS KPKNAFLAPA CLPGLTHIEA TVNALVDIIH GYCTCELDCI 2700 NTASKIYMQM LLCPDPAVSF SCKQALIRVL RPRNKRRHVT LPSSPRSNTP MGDKDDDDDD 2760 DADEKMQSSG IPDGGHIRQE SQEQSEVDHG DFEMVSESMV LETAENVNNG NPSPLEALLA 2820 GAEGFPPMLD IPPDADDETM VELAIALSLQ QDQQGSSSSA LGLQSLGLSG QAPSSSSLDA 2880 GTLSDTTASA PASDDEGSTA ATDGSTLRTS PADHGGSVGS ESGGSAVDSV AGEHSVSGRS 2940 SAYGDATAEG HPAGPGSVSS STGAISTATG HQEGDGSEGE GEGEAEGDVH TSNRLHMVRL 3000 MLLERLLQTL PQLRNVGGVR AIPYMQVILM LTTDLDGEDE KDKGALDNLL AQLIAELGMD 3060 KKDVSKKNER SALNEVHLVV MRLLSVFMSR TKSGSKSSIC ESSSLISSAT AAALLSSGAV 3120 DYCLHVLKSL LEYWKSQQSD EEPVAASQLL KPHTTSSPPD MSPFFLRQYV KGHAADVFEA 3180 YTQLLTEMVL RLPYQIKKIA DTSSRIPPPV FDHSWFYFLS EYLMIQQTPF VRRQVRKLLL 3240 FICGSKEKYR QLRDLHTLDS HVRGIKKLLE EQGIFLRASV VTASSGSALQ YDTLISLMEH 3300 LKACAEIAAQ RTINWQKFCI KDDSVLYFLL QVSFLVDEGV SPVLLQLLSC ALCGSKVLAA 3360 LAASTGSSSV ASSSAPPAAS SGQATTQSKS STKKSKKEEK EKEKEGESSG SQEDQLCTAL 3420 VNQLNRFADK ETLIQFLRCF LLESNSSSVR WQAHCLTLHI YRNSNKAQQE LLLDLMWSIW 3480 PELPAYGRKA AQFVDLLGYF SLKTAQTEKK LKEYSQKAVE ILRTQNHILT NHPNSNIYNT 3540 LSGLVEFDGY YLESDPCLVC NNPEVPFCYI KLSSIKVDTR YTTTQQVVKL IGSHTISKVT 3600 VKIGDLKRTK MVRTINLYYN NRTVQAIVEL KNKPARWHKA KKVQLTPGQT EVKIDLPLPI 3660 VASNLMIEFA DFYENYQAST ETLQCPRCSA SVPANPGVCG NCGENVYQCH KCRSINYDEK 3720 DPFLCNACGF CKYARFDFML YAKPCCAVDP IENEEDRKKA VSNINTLLDK ADRVYHQLMG 3780 HRPQLENLLC KVNEAAPEKP QEDSGTAGGI SSTSASVNRY ILQLAQEYCG DCKNSFDELS 3840 KIIQKVFASR KELLEYDLQQ REAATKSSRT SVQPTFTASQ YRALSVLGCG HTSSTKCYGC 3900 ASAVTEHCIT LLRALATNPA LRHILVSQGL IRELFDYNLR RGAAAIREEV RQLMCLLTRD 3960 NPEATQQMND LIIGKVSTAL KGHWANPDLA SSLQYEMLLL TDSISKEDSC WELRLRCALS 4020 LFLMAVNIKT PVVVENITLM CLRILQKLIK PPAPTSKKNK DVPVEALTTV KPYCNEIHAQ 4080 AQLWLKRDPK ASYEAWKKCL PIRGVDGNGK SPSKSELHRL YLTEKYVWRW KQFLSRRGKR 4140 TTPLDLKLGH NNWLRQVLFT PATQAARQAA CTIVEALATV PSRKQQVLDL LTSYLDELSV 4200 AGECAAEYLA LYQKLIASCH WKVYLAARGV LPYVGNLITK EIARLLALEE ATLSTDLQQG 4260 YALKSLTGLL SSFVEVESIK RHFKSRLVGT VLNGYLCLRK LVLQRTKLID ETQDMLLEML 4320 EDMTTGTESE TKAFMAVCIE TAKRYNLDDY RTPVFIFERL CSIIYPEENE VTEFFVTLEK 4380 DPQQEDFLQG RMPGNPYSSN EPGIGPLMRD IKNKICQDCD LVALLEDDSG MELLVNNKII 4440 SLDLPVAEVY KKVWCATNEG EPMRIVYRMR GLLGDATEEF IESLDSTTDE EEDEEEVYRM 4500 AGVMAQCGGL QCMLNRLAGV KDFKQGRHLL TVLLKLFSYC VKVKVNRQQL VKLETNTLNV 4560 MLGTLNLALV AEQESKDSGG AAVAEQVLSI MEIILDESNA EPLSEDKGNL LLTGDKDQLV 4620 MLLDQINSTF VRSNPSVLQG LLRIIPYLSF GEVEKMQILV ERFKPYCSFE KYDEDHSGDD 4680 KVFLDCFCKI AAGIKNNSNG HQLKDLILQK GITQNALDYM KKHIPSAKNL DADIWKKFLS 4740 RPALPFILRL LRGLAMQHPA TQVLIGTDSI TSLHKLEQVS SDEGIGTLAE NLLEALREHP 4800 DVNKKIDAAR RETRAEKKRM AMAMRQKALG TLGMTTNEKG QVVTKTALLK QMEELIEEPG 4860 LTCCICREGY KFQPTKVLGI YTFTKRVALE EMENKPRKQQ GYSTVSHFNI VHYDCHLAAV 4920 RLARGREEWE SAALQNANTK CNGLLPVWGP HVPESAFATC LARHNTYLQE CTGQREPTYQ 4980 LNIHDIKLLF LRFAMEQSFS ADTGGGGRES NIHLIPYIIH TVLYVLNTTR ATSREEKNLQ 5040 GFLEQPKEKW TESAFDVDGP HYFTILALHV LPPEQWKAIR VEILRRLLVA SHARAVAPGG 5100 ATRLTDKAVK DYSAYRSSLL FWALVDLIYN MFKKVPTSNT EGGWSCSLAE YIRHNDMPIY 5160 EAADKALKTF QEEFMPVETF SEFLDAAGLL SEITDPESFL KDLLNSVP 5208 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |