CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014264
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Caprin-1 
Protein Synonyms/Alias
 Cytoplasmic activation- and proliferation-associated protein 1; GPI-anchored membrane protein 1; GPI-anchored protein p137; GPI-p137; p137GPI; Membrane component chromosome 11 surface marker 1; RNA granule protein 105 
Gene Name
 Caprin1 
Gene Synonyms/Alias
 Gpiap; Gpiap1; Gpip137; M11s1; Rng105; G5E5 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
61QILGVIDKKLRNLEKubiquitination[1]
72NLEKKKGKLDDYQERacetylation[2]
72NLEKKKGKLDDYQERubiquitination[1]
108TNNLEFAKELQRSFMubiquitination[1]
123ALSQDIQKTIKKTARubiquitination[1]
126QDIQKTIKKTARREQubiquitination[1]
221DLLEGKEKPVCGTTYubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. 
Sequence Annotation
 REGION 358 379 G3BP1-binding (By similarity).
 MOD_RES 2 2 N-acetylproline (By similarity).
 MOD_RES 10 10 Phosphoserine (By similarity).  
Keyword
 Acetylation; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Differentiation; Glycoprotein; Phosphoprotein; Protein synthesis inhibitor; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 707 AA 
Protein Sequence
MPSATSHSGS GSKSSGPPPP SGSSGSEAAA GAAAPASQHP ATGTGAVQTE AMKQILGVID 60
KKLRNLEKKK GKLDDYQERM NKGERLNQDQ LDAVSKYQEV TNNLEFAKEL QRSFMALSQD 120
IQKTIKKTAR REQLMREEAE QKRLKTVLEL QYVLDKLGDD DVRTDLKQGL SGVPILSEEE 180
LSLLDEFYKL VDPERDMSLR LNEQYEHASI HLWDLLEGKE KPVCGTTYKA LKEIVERVFQ 240
SNYFDSTHNH QNGLCEEEEA ASAPTVEDQV AEAEPEPAEE YTEQSEVEST EYVNRQFMAE 300
TQFSSGEKEQ VDEWTVETVE VVNSLQQQPQ AASPSVPEPH SLTPVAQSDP LVRRQRVQDL 360
MAQMQGPYNF IQDSMLDFEN QTLDPAIVSA QPMNPTQNMD MPQLVCPQVH SESRLAQSNQ 420
VPVQPEATQV PLVSSTSEGY TASQPLYQPS HATEQRPQKE PMDQIQATIS LNTDQTTASS 480
SLPAASQPQV FQAGTSKPLH SSGINVNAAP FQSMQTVFNM NAPVPPANEP ETLKQQSQYQ 540
ATYNQSFSSQ PHQVEQTELQ QDQLQTVVGT YHGSQDQPHQ VPGNHQQPPQ QNTGFPRSSQ 600
PYYNSRGVSR GGSRGARGLM NGYRGPANGF RGGYDGYRPS FSNTPNSGYS QSQFTAPRDY 660
SGYQRDGYQQ NFKRGSGQSG PRGAPRGRGG PPRPNRGMPQ MNTQQVN 707 
Gene Ontology
 GO:0000932; C:cytoplasmic mRNA processing body; ISS:UniProtKB.
 GO:0010494; C:cytoplasmic stress granule; ISS:UniProtKB.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; ISS:UniProtKB.
 GO:0017148; P:negative regulation of translation; ISS:UniProtKB.
 GO:0050775; P:positive regulation of dendrite morphogenesis; IMP:UniProtKB.
 GO:0061003; P:positive regulation of dendritic spine morphogenesis; IMP:UniProtKB. 
Interpro
 IPR022070; Caprin-1_C. 
Pfam
 PF12287; Caprin-1_C 
SMART
  
PROSITE
  
PRINTS