UniProt Accession

 TMOD3_MOUSE; Q9JHJ0; Q3TIT1 

Genbank Protein ID

 AF237630; AF177172; AK050372; AK167723; BC082595 

Genbank Nucleotide ID

 AAF45298.1; AAF31671.1; BAC34216.1; BAE39765.1; AAH82595.1 

Protein Name

 Tropomodulin-3 

Protein Synonyms/Alias

 Ubiquitous tropomodulin; U-Tmod 

Gene Name

 Tmod3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
23	DEDELLGKLSESELK	ubiquitination	[1]
75	RLLSYLEKQALEHKD	ubiquitination	[1]
172	PNVVKGEKILPVFDE	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). 

Sequence Annotation

 MOD_RES 25 25 Phosphoserine (By similarity).
 MOD_RES 71 71 Phosphoserine.  

Keyword

 Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 352 AA 

Protein Sequence

Gene Ontology

 GO:0005865; C:striated muscle thin filament; IDA:MGI.
 GO:0005523; F:tropomyosin binding; IDA:MGI. 

Interpro

 IPR004934; Tropomodulin. 

Pfam

 PF03250; Tropomodulin 

SMART

  

PROSITE

  

PRINTS