UniProt Accession

 DCXR_MOUSE; Q91X52; Q3U5L5; Q9D129; Q9D8W1 

Genbank Protein ID

 D89656; AK004023; AK007627; AK153521; BC012247 

Genbank Nucleotide ID

 BAB88678.1; BAB23131.1; BAB25146.1; BAE32063.1; AAH12247.1 

Protein Name

 L-xylulose reductase 

Protein Synonyms/Alias

 XR; Dicarbonyl/L-xylulose reductase 

Gene Name

 Dcxr 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
17	ALVTGAGKGIGRSTV	ubiquitination	[1]
171	ALELGPHKIRVNAVN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. 

Sequence Annotation

 NP_BIND 11 39 NADP (By similarity).
 ACT_SITE 149 149 Proton acceptor (By similarity).
 ACT_SITE 153 153 By similarity.
 BINDING 136 136 Substrate (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 Acetylation; Carbohydrate metabolism; Cell membrane; Complete proteome; Glucose metabolism; Membrane; NADP; Oxidoreductase; Reference proteome; Xylose metabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 244 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005903; C:brush border; IDA:MGI.
 GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
 GO:0005902; C:microvillus; IDA:MGI.
 GO:0050038; F:L-xylulose reductase (NADP+) activity; IDA:UniProtKB.
 GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:Compara.
 GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
 GO:0006006; P:glucose metabolic process; IDA:UniProtKB.
 GO:0006739; P:NADP metabolic process; IDA:MGI.
 GO:0051289; P:protein homotetramerization; IDA:UniProtKB.
 GO:0005997; P:xylulose metabolic process; IDA:MGI. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

  

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.