CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034030
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 WD repeat domain phosphoinositide-interacting protein 2 
Protein Synonyms/Alias
  
Gene Name
 Wipi2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
198AFDASGTKLATASEKubiquitination[1]
323CSLTTIQKIPRLLVGacetylation[2]
323CSLTTIQKIPRLLVGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 425 AA 
Protein Sequence
MNLASQSGEA GAGQLLFANF NQDNTSLAVG SKSGYKFFSL SSVDKLEQIY ECTDTEDVCI 60
VERLFSSSLV AIVSLKAPRK LKVCHFKKGT EICNYSYSNT ILAVKLNRQR LIVCLEESLY 120
IHNIRDMKVL HTIRETPPNP AGLCALSINN DNCYLAYPGS ASIGEVQVFD TINLRAANMI 180
PAHDSPLAAL AFDASGTKLA TASEKGTVIR VFSIPEGQKL FEFRRGVKRC VSICSLAFSM 240
DGMFLSASSN TETVHIFKLE AVREKPPEEP TTWTGYFGKV LMASTSYLPS QVTEMFNQGR 300
AFATVRLPFC GHKNICSLTT IQKIPRLLVG ASDGYLYMYN LDPQEGGECA LMRQHRLDGS 360
METTSEIVDS ASHDCPLATQ TYGTAAAKAY TDDLGAVGGA CLEDEASALR LDEDSEHPPM 420
ILRTD 425 
Gene Ontology
 GO:0000421; C:autophagic vacuole membrane; IBA:RefGenome.
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0034045; C:pre-autophagosomal structure membrane; IBA:RefGenome.
 GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IBA:RefGenome.
 GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:RefGenome.
 GO:0000045; P:autophagic vacuole assembly; IBA:RefGenome. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
  
PRINTS