CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012783
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cell adhesion molecule 2 
Protein Synonyms/Alias
 Immunoglobulin superfamily member 4D; IgSF4D; Nectin-like protein 3; NECL-3; Synaptic cell adhesion molecule 2; SynCAM 2 
Gene Name
 Cadm2 
Gene Synonyms/Alias
 Igsf4d; Necl3 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
396GRYLARHKGTYLTNEubiquitination[1]
405TYLTNEAKGAEDAPDubiquitination[1]
430SQVNAEEKKEYFI**ubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes (By similarity). 
Sequence Annotation
 DOMAIN 27 119 Ig-like V-type.
 DOMAIN 127 219 Ig-like C2-type 1.
 DOMAIN 227 312 Ig-like C2-type 2.
 CARBOHYD 31 31 N-linked (GlcNAc...) (Potential).
 CARBOHYD 51 51 N-linked (GlcNAc...) (Potential).
 CARBOHYD 291 291 N-linked (GlcNAc...) (Potential).
 DISULFID 44 104 By similarity.
 DISULFID 146 203 By similarity.
 DISULFID 248 296 By similarity.  
Keyword
 Alternative splicing; Cell adhesion; Cell junction; Cell membrane; Cell projection; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Reference proteome; Repeat; Signal; Synapse; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 435 AA 
Protein Sequence
MIWKRSAVLR FYSVCGLLLL GSQGQFPLTQ NVTVVEGGTA ILTCRVDQND NTSLQWSNPA 60
QQTLYFDDKK ALRDNRIELV RASWHELSIS VSDVSLSDEG QYTCSLFTMP VKTSKAYLTV 120
LGVPEKPQIS GFSSPVMEGD LMQLTCKTSG SKPAADIRWF KNDKEIKDVK YLKEEDANRK 180
TFTVSSTLDF RVDRSDDGVA VICRVDHESL NATPQVAMQV LEIHYTPSVK IIPSTPFPQE 240
GQALTLTCES KGKPLPEPVL WTKDGAELPD PDRMVVSGRE LNILFLNKTD NGTYRCEATN 300
TIGQSSAEYV LIVHDVPNTL LPTTIIPSLT TAPVTTTVAI TTSPSTSASS SSRRDPNSLA 360
GQNGPDHALI GGIVAVVVFV TLCSIFLLGR YLARHKGTYL TNEAKGAEDA PDADTAIINA 420
EGSQVNAEEK KEYFI 435 
Gene Ontology
 GO:0030424; C:axon; IDA:RGD.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0032809; C:neuronal cell body membrane; IDA:RGD.
 GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
 GO:0007420; P:brain development; IEP:RGD.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. 
Interpro
 IPR013162; CD80_C2-set.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR013106; Ig_V-set.
 IPR003585; Neurexin-like. 
Pfam
 PF08205; C2-set_2
 PF07679; I-set
 PF07686; V-set 
SMART
 SM00294; 4.1m
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50835; IG_LIKE 
PRINTS