UniProt Accession

 HEM4_MOUSE; P51163 

Genbank Protein ID

 U18867; U16216; U04439; BC068161 

Genbank Nucleotide ID

 AAA74742.1; AAA79978.1; AAA81898.1; AAH68161.1 

Protein Name

 Uroporphyrinogen-III synthase 

Protein Synonyms/Alias

 UROIIIS; UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase 

Gene Name

 Uros 

Gene Synonyms/Alias

 Uros3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
7	*MKVLLLKDAKEDDS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Heme biosynthesis; Lyase; Porphyrin biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 265 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0048037; F:cofactor binding; IEA:Compara.
 GO:0004852; F:uroporphyrinogen-III synthase activity; IDA:MGI.
 GO:0071418; P:cellular response to amine stimulus; IEA:Compara.
 GO:0071243; P:cellular response to arsenic-containing substance; IEA:Compara.
 GO:0006779; P:porphyrin-containing compound biosynthetic process; IDA:MGI.
 GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0046677; P:response to antibiotic; IEA:Compara.
 GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:Compara. 

Interpro

 IPR003754; 4pyrrol_synth_uPrphyn_synth. 

Pfam

 PF02602; HEM4 

SMART

  

PROSITE

  

PRINTS