UniProt Accession

 IF4B_HUMAN; P23588; Q4G0E3; Q53HQ2; Q6GPH5; Q6IB46; Q8WYK5 

Genbank Protein ID

 X55733; AB076839; CR456958; AK222528; CH471054; BC073139; BC073154; BC098437 

Genbank Nucleotide ID

 CAA39265.1; BAB82380.1; CAG33239.1; BAD96248.1; EAW96657.1; AAH73139.1; AAH73154.1; AAH98437.1 

Protein Name

 Eukaryotic translation initiation factor 4B 

Protein Synonyms/Alias

 eIF-4B 

Gene Name

 EIF4B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
223	GDDSFGDKYRDRYDS	ubiquitination	[1]
578	RSAPEPKKPEENPAS	acetylation	[2]
586	PEENPASKFSSASKY	acetylation	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F. 

Sequence Annotation

 DOMAIN 96 173 RRM.
 MOD_RES 93 93 Phosphoserine.
 MOD_RES 192 192 Phosphoserine.
 MOD_RES 219 219 Phosphoserine.
 MOD_RES 283 283 Phosphoserine.
 MOD_RES 406 406 Phosphoserine.
 MOD_RES 412 412 Phosphothreonine.
 MOD_RES 418 418 Phosphoserine.
 MOD_RES 422 422 Phosphoserine; by RPS6KA1 and RPS6KB1.
 MOD_RES 425 425 Phosphoserine.
 MOD_RES 445 445 Phosphoserine.
 MOD_RES 459 459 Phosphoserine.
 MOD_RES 497 497 Phosphoserine (By similarity).
 MOD_RES 498 498 Phosphoserine.
 MOD_RES 504 504 Phosphoserine.
 MOD_RES 586 586 N6-acetyllysine.
 MOD_RES 597 597 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Initiation factor; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 611 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016281; C:eukaryotic translation initiation factor 4F complex; TAS:ProtInc.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003743; F:translation initiation factor activity; TAS:ProtInc.
 GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
 GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; TAS:Reactome.
 GO:0006446; P:regulation of translational initiation; TAS:ProtInc. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS