| Tag | Content |
|---|
| CPLM ID | CPLM-020007 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | UBX domain-containing protein 6 |
Protein Synonyms/Alias | UBX domain-containing protein 1 |
Gene Name | Ubxn6 |
Gene Synonyms/Alias | Ubxd1; Ubxdc2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 160 | PVAASIMKIHTFNRD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation (By similarity). |
Sequence Annotation | DOMAIN 175 244 PUB.
DOMAIN 332 408 UBX.
MOD_RES 36 36 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 442 AA |
Protein Sequence | MKKFFQEIKA DIKFKSAGPG QKLTDSAGEK TTKGKSPQLA LRQPRQGPTD EAQMAAAAAL 60
ARLEQKQPRA RGPTSQDSIR NQVRKELQAE ATSSNNPGAP GTNSVPEPKE EISPHLAVPG 120
VFFICPLTGV TLRRDQRDAH IKQAILSHFS TDPVAASIMK IHTFNRDRDR VKLGVDTIAK 180
YLDNIHLHPE EEKYQKIKLQ NKVFQERINC LEGSHEFFEA IGFKKVTLPV PDQEGQEEFY 240
VLGEDARAQP QNLARHKQQL LDAEPVRATL DRQLRVFRPS ALASHFELPS DFFSLTAEEV 300
KREQRLRTEA VERLSSLRTK AMREKEEQRE LRKYTYALVR VRLPDGCLLQ GTFYAREKLS 360
ALFRFVREAL QNDWLPFELR ASGGQKLEEN EALALNECGL VPSALLTFSW DASVLEDIRA 420
AGAEPAKSVL RPELLAAIEQ LS 442 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. GO:0005730; C:nucleolus; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |