CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012839
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CST complex subunit CTC1 
Protein Synonyms/Alias
 Conserved telomere maintenance component 1; HBV DNAPTP1-transactivated protein B 
Gene Name
 CTC1 
Gene Synonyms/Alias
 C17orf68 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
32KTLCPAVKEPNVQLTubiquitination[1, 2]
47PLVIDCVKTVWLSQGubiquitination[1]
74FVSVQDLKTHQRLPCubiquitination[1, 2, 3, 4]
238VRLSALVKSKQKAYFubiquitination[1, 3]
480ALEELACKLCPHVLRubiquitination[1, 2]
539PHHCPLQKYTRLQTPubiquitination[1, 2]
556FPTLATLKEEGQRKAubiquitination[1, 2, 3]
562LKEEGQRKAWASFDPubiquitination[1, 2]
637LPCLLLAKHSQPLSDubiquitination[1]
673RSSFPSWKELSMPGFubiquitination[1, 3]
683SMPGFIQKQQARVYVubiquitination[1]
776WLGGTQRKEGTGWGLubiquitination[3]
795GNDDNDQKVHLIFFGubiquitination[3]
918LVASLWMKLGNTGAMubiquitination[1]
974VHFSQLEKRVSRSHNubiquitination[1, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. 
Sequence Annotation
  
Keyword
 Alternative splicing; Chromosome; Complete proteome; Disease mutation; DNA-binding; Nucleus; Polymorphism; Reference proteome; Telomere. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1217 AA 
Protein Sequence
MAAGRAQVPS SEQAWLEDAQ VFIQKTLCPA VKEPNVQLTP LVIDCVKTVW LSQGRNQGST 60
LPLSYSFVSV QDLKTHQRLP CCSHLSWSSS AYQAWAQEAG PNGNPLPREQ LLLLGTLTDL 120
SADLEQECRN GSLYVRDNTG VLSCELIDLD LSWLGHLFLF PRWSYLPPAR WNSSGEGHLE 180
LWDAPVPVFP LTISPGPVTP IPVLYPESAS CLLRLRNKLR GVQRNLAGSL VRLSALVKSK 240
QKAYFILSLG RSHPAVTHVS IIVQVPAQLV WHRALRPGTA YVLTELRVSK IRGQRQHVWM 300
TSQSSRLLLL KPECVQELEL ELEGPLLEAD PKPLPMPSNS EDKKDPESLV RYSRLLSYSG 360
AVTGVLNEPA GLYELDGQLG LCLAYQQFRG LRRVMRPGVC LQLQDVHLLQ SVGGGTRRPV 420
LAPCLRGAVL LQSFSRQKPG AHSSRQAYGA SLYEQLVWER QLGLPLYLWA TKALEELACK 480
LCPHVLRHHQ FLQHSSPGSP SLGLQLLAPT LDLLAPPGSP VRNAHNEILE EPHHCPLQKY 540
TRLQTPSSFP TLATLKEEGQ RKAWASFDPK ALLPLPEASY LPSCQLNRRL AWSWLCLLPS 600
AFCPAQVLLG VLVASSHKGC LQLRDQSGSL PCLLLAKHSQ PLSDPRLIGC LVRAERFQLI 660
VERDVRSSFP SWKELSMPGF IQKQQARVYV QFFLADALIL PVPRPCLHSA TPSTPQTDPT 720
GPEGPHLGQS RLFLLCHKEA LMKRNFCVPP GASPEVPKPA LSFYVLGSWL GGTQRKEGTG 780
WGLPEPQGND DNDQKVHLIF FGSSVRWFEF LHPGQVYRLI APGPATPMLF EKDGSSCISR 840
RPLELAGCAS CLTVQDNWTL ELESSQDIQD VLDANKSLPE SSLTDLLSDN FTDSLVSFSA 900
EILSRTLCEP LVASLWMKLG NTGAMRRCVK LTVALETAEC EFPPHLDVYI EDPHLPPSLG 960
LLPGARVHFS QLEKRVSRSH NVYCCFRSST YVQVLSFPPE TTISIPLPHI YLAELLQGGQ 1020
SPFQATASCH IVSVFSLQLF WVCAYCTSIC RQGKCTRLGS TCPTQTAISQ AIIRLLVEDG 1080
TAEAVVTCRN HHVAAALGLC PREWASLLDF VQVPGRVVLQ FAGPGAQLES SARVDEPMTM 1140
FLWTLCTSPS VLRPIVLSFE LERKPSKIVP LEPPRLQRFQ CGELPFLTHV NPRLRLSCLS 1200
IRESEYSSSL GILASSC 1217 
Gene Ontology
 GO:0070188; C:Stn1-Ten1 complex; ISS:UniProtKB.
 GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
 GO:0045740; P:positive regulation of DNA replication; ISS:UniProtKB.
 GO:0000723; P:telomere maintenance; IMP:UniProtKB. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS