| Tag | Content |
|---|
| CPLM ID | CPLM-016557 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Adiponectin receptor protein 2 |
Protein Synonyms/Alias | |
Gene Name | Adipor2 |
Gene Synonyms/Alias | D6Ucla1e |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 97 | RMEEFVCKVWEGRWR | ubiquitination | [1] | | 137 | PSFRACFKSIFRIHT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin. |
Sequence Annotation | |
Keyword | Alternative splicing; Complete proteome; Fatty acid metabolism; Lipid metabolism; Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 386 AA |
Protein Sequence | MNEPAKHRLG CTRTPEPDIR LRKGHQLDDT RGSNNDNYQG DLEPSLETPV CSSYYENSPE 60
EPECHDDNSQ EDEGFMGMSP LLQAHHAMER MEEFVCKVWE GRWRVIPHDV LPDWLKDNDF 120
LLHGHRPPMP SFRACFKSIF RIHTETGNIW THLLGCVFFL CLGIFYMFRP NISFVAPLQE 180
KVVFGLFFLG AILCLSFSWL FHTVYCHSEG VSRLFSKLDY SGIALLIMGS FVPWLYYSFY 240
CNPQPCFIYL IVICVLGIAA IIVSQWDMFA TPQYRGVRAG VFVGLGLSGI IPTLHYVISE 300
GFLKAATIGQ IGWLMLMASL YITGAALYAA RIPERFFPGK CDIWFHSHQL FHIFVVAGAF 360
VHFHGVSNLQ EFRFMIGGGC TEEDAL 386 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0042562; F:hormone binding; ISS:UniProtKB. GO:0042802; F:identical protein binding; IDA:MGI. GO:0004872; F:receptor activity; IDA:MGI. GO:0019395; P:fatty acid oxidation; ISS:UniProtKB. GO:0009755; P:hormone-mediated signaling pathway; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |