UniProt Accession

 CAH8_HUMAN; P35219; A8K0A5; B3KQZ7; Q32MY2 

Genbank Protein ID

 L04656; AY075022; AK289470; AK314538; AK090655; CH471068; BC069744; BC069794; BC108929 

Genbank Nucleotide ID

 AAA35653.2; AAL78170.1; BAF82159.1; BAG37128.1; BAG52209.1; EAW86826.1; AAH69744.1; AAH69794.1; AAI08930.1 

Protein Name

 Carbonic anhydrase-related protein 

Protein Synonyms/Alias

 CARP; Carbonic anhydrase VIII; CA-VIII 

Gene Name

 CA8 

Gene Synonyms/Alias

 CALS 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
96	IQVILKSKSVLSGGP	ubiquitination	[1, 2]
196	IQYKGKSKTIPCFNP	ubiquitination	[3]
258	RRLRTHVKGAELVEG	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Does not have a carbonic anhydrase catalytic activity. 

Sequence Annotation

 METAL 118 118 Zinc (Potential).
 METAL 141 141 Zinc (Potential).  

Keyword

 3D-structure; Complete proteome; Disease mutation; Mental retardation; Metal-binding; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 290 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0004089; F:carbonate dehydratase activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006730; P:one-carbon metabolic process; IEA:InterPro.
 GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:Compara. 

Interpro

 IPR001148; Carbonic_anhydrase_a.
 IPR023561; Carbonic_anhydrase_a-class.
 IPR018338; Carbonic_anhydrase_a-class_CS.
 IPR018434; Carbonic_anhydrase_RP_CA8. 

Pfam

 PF00194; Carb_anhydrase 

SMART

 SM01057; Carb_anhydrase 

PROSITE

 PS00162; ALPHA_CA_1
 PS51144; ALPHA_CA_2 

PRINTS