CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036913
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Peroxisomal multifunctional enzyme type 2 
Protein Synonyms/Alias
  
Gene Name
 HSD17B4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
153EQYLELYKPLPRAGKacetylation[1, 2]
303AIKARFAKPVYPGQTacetylation[1, 2, 3]
303AIKARFAKPVYPGQTubiquitination[2, 4]
317TLQTEMWKEGNRIHFacetylation[2]
374EEIGRRLKDIGPEVVacetylation[2]
382DIGPEVVKKVNAVFEacetylation[2]
407AKWTIDLKSGSGKVYacetylation[3]
445LGKLDPQKAFFSGRLacetylation[1, 2]
469QKLQMILKDYAKL**acetylation[3]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 474 AA 
Protein Sequence
MISAHYNLCP LGSSDSPTSA SQVAGITEST GSIIEVLSKI DSEGGVSANH TSRATSTATS 60
GFAGAIGQKL PPFSYAYTEL EAIMYALGVG ASIKDPKDLK FIYEGSSDFS CLPTFGVIIG 120
QKSMMGGGLA EIPGLSINFA KVLHGEQYLE LYKPLPRAGK LKCEAVVADV LDKGSGVVII 180
MDVYSYSEKE LICHNQFSLF LVGSGGFGGK RTSDKVKVAV AIPNRPPDAV LTDTTSLNQA 240
ALYRLSGDWN PLHIDPNFAS LAGFDKPILH GLCTFGFSAR RVLQQFADND VSRFKAIKAR 300
FAKPVYPGQT LQTEMWKEGN RIHFQTKVQE TGDIVISNAY VDLAPTSGTS AKTPSEGGKL 360
QSTFVFEEIG RRLKDIGPEV VKKVNAVFEW HITKGGNIGA KWTIDLKSGS GKVYQGPAKG 420
AADTTIILSD EDFMEVVLGK LDPQKAFFSG RLKARGNIML SQKLQMILKD YAKL 474 
Gene Ontology
 GO:0016491; F:oxidoreductase activity; IEA:InterPro.
 GO:0032934; F:sterol binding; IEA:InterPro.
 GO:0055114; P:oxidation-reduction process; IEA:GOC. 
Interpro
 IPR002539; MaoC_dom.
 IPR027090; Mfe-2.
 IPR003033; SCP2_sterol-bd_dom. 
Pfam
 PF01575; MaoC_dehydratas
 PF02036; SCP2 
SMART
  
PROSITE
  
PRINTS