CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010774
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Clathrin heavy chain 1 
Protein Synonyms/Alias
 Clathrin heavy chain on chromosome 17; CLH-17 
Gene Name
 CLTC 
Gene Synonyms/Alias
 CLH17; CLTCL2; KIAA0034 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
96QIFNIEMKSKMKAHTubiquitination[1]
367AEELFARKFNALFAQubiquitination[1]
389KVAANAPKGILRTPDubiquitination[1]
507KIVLYAKKVGYTPDWubiquitination[1]
619HIAQLCEKAGLLQRAubiquitination[1]
637FTDLYDIKRAVVHTHubiquitination[1]
798LYRNNLQKYIEIYVQubiquitination[1]
806YIEIYVQKVNPSRLPubiquitination[1]
856VEKRNRLKLLLPWLEubiquitination[1]
1034LLILTAIKADRTRVMubiquitination[1]
1215EKMYDAAKLLYNNVSubiquitination[1]
1441RAVNYFSKVKQLPLVubiquitination[1]
1461SVQNHNNKSVNESLNubiquitination[1]
1535CKKDSLYKDAMQYASubiquitination[1]
1609VMKEYLTKVDKLDASubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. 
Sequence Annotation
 REPEAT 537 683 CHCR 1.
 REPEAT 686 828 CHCR 2.
 REPEAT 833 972 CHCR 3.
 REPEAT 979 1124 CHCR 4.
 REPEAT 1128 1269 CHCR 5.
 REPEAT 1274 1420 CHCR 6.
 REPEAT 1423 1566 CHCR 7.
 REGION 2 479 Globular terminal domain.
 REGION 24 67 WD40-like repeat 1.
 REGION 68 107 WD40-like repeat 2.
 REGION 108 149 WD40-like repeat 3.
 REGION 150 195 WD40-like repeat 4.
 REGION 196 257 WD40-like repeat 5.
 REGION 258 301 WD40-like repeat 6.
 REGION 302 330 WD40-like repeat 7.
 REGION 449 465 Binding site for the uncoating ATPase,
 REGION 480 523 Flexible linker.
 REGION 524 1675 Heavy chain arm.
 REGION 524 634 Distal segment.
 REGION 639 1675 Proximal segment.
 REGION 1213 1522 Involved in binding clathrin light chain
 REGION 1550 1675 Trimerization (By similarity).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 184 184 Phosphotyrosine (By similarity).
 MOD_RES 394 394 Phosphothreonine.
 MOD_RES 634 634 Phosphotyrosine.
 MOD_RES 856 856 N6-acetyllysine.
 MOD_RES 899 899 Phosphotyrosine (By similarity).
 MOD_RES 1206 1206 Phosphotyrosine (By similarity).
 MOD_RES 1441 1441 N6-acetyllysine.
 MOD_RES 1477 1477 Phosphotyrosine.
 MOD_RES 1487 1487 Phosphotyrosine (By similarity).
 MOD_RES 1494 1494 Phosphoserine.
 MOD_RES 1501 1501 N6-acetyllysine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Coated pit; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1675 AA 
Protein Sequence
MAQILPIRFQ EHLQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV VIIDMNDPSN 60
PIRRPISADS AIMNPASKVI ALKAGKTLQI FNIEMKSKMK AHTMTDDVTF WKWISLNTVA 120
LVTDNAVYHW SMEGESQPVK MFDRHSSLAG CQIINYRTDA KQKWLLLTGI SAQQNRVVGA 180
MQLYSVDRKV SQPIEGHAAS FAQFKMEGNA EESTLFCFAV RGQAGGKLHI IEVGTPPTGN 240
QPFPKKAVDV FFPPEAQNDF PVAMQISEKH DVVFLITKYG YIHLYDLETG TCIYMNRISG 300
ETIFVTAPHE ATAGIIGVNR KGQVLSVCVE EENIIPYITN VLQNPDLALR MAVRNNLAGA 360
EELFARKFNA LFAQGNYSEA AKVAANAPKG ILRTPDTIRR FQSVPAQPGQ TSPLLQYFGI 420
LLDQGQLNKY ESLELCRPVL QQGRKQLLEK WLKEDKLECS EELGDLVKSV DPTLALSVYL 480
RANVPNKVIQ CFAETGQVQK IVLYAKKVGY TPDWIFLLRN VMRISPDQGQ QFAQMLVQDE 540
EPLADITQIV DVFMEYNLIQ QCTAFLLDAL KNNRPSEGPL QTRLLEMNLM HAPQVADAIL 600
GNQMFTHYDR AHIAQLCEKA GLLQRALEHF TDLYDIKRAV VHTHLLNPEW LVNYFGSLSV 660
EDSLECLRAM LSANIRQNLQ ICVQVASKYH EQLSTQSLIE LFESFKSFEG LFYFLGSIVN 720
FSQDPDVHFK YIQAACKTGQ IKEVERICRE SNCYDPERVK NFLKEAKLTD QLPLIIVCDR 780
FDFVHDLVLY LYRNNLQKYI EIYVQKVNPS RLPVVIGGLL DVDCSEDVIK NLILVVRGQF 840
STDELVAEVE KRNRLKLLLP WLEARIHEGC EEPATHNALA KIYIDSNNNP ERFLRENPYY 900
DSRVVGKYCE KRDPHLACVA YERGQCDLEL INVCNENSLF KSLSRYLVRR KDPELWGSVL 960
LESNPYRRPL IDQVVQTALS ETQDPEEVSV TVKAFMTADL PNELIELLEK IVLDNSVFSE 1020
HRNLQNLLIL TAIKADRTRV MEYINRLDNY DAPDIANIAI SNELFEEAFA IFRKFDVNTS 1080
AVQVLIEHIG NLDRAYEFAE RCNEPAVWSQ LAKAQLQKGM VKEAIDSYIK ADDPSSYMEV 1140
VQAANTSGNW EELVKYLQMA RKKARESYVE TELIFALAKT NRLAELEEFI NGPNNAHIQQ 1200
VGDRCYDEKM YDAAKLLYNN VSNFGRLAST LVHLGEYQAA VDGARKANST RTWKEVCFAC 1260
VDGKEFRLAQ MCGLHIVVHA DELEELINYY QDRGYFEELI TMLEAALGLE RAHMGMFTEL 1320
AILYSKFKPQ KMREHLELFW SRVNIPKVLR AAEQAHLWAE LVFLYDKYEE YDNAIITMMN 1380
HPTDAWKEGQ FKDIITKVAN VELYYRAIQF YLEFKPLLLN DLLMVLSPRL DHTRAVNYFS 1440
KVKQLPLVKP YLRSVQNHNN KSVNESLNNL FITEEDYQAL RTSIDAYDNF DNISLAQRLE 1500
KHELIEFRRI AAYLFKGNNR WKQSVELCKK DSLYKDAMQY ASESKDTELA EELLQWFLQE 1560
EKRECFGACL FTCYDLLRPD VVLETAWRHN IMDFAMPYFI QVMKEYLTKV DKLDASESLR 1620
KEEEQATETQ PIVYGNLSL 1639 
Gene Ontology
 GO:0030118; C:clathrin coat; NAS:UniProtKB.
 GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
 GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
 GO:0030669; C:clathrin-coated endocytic vesicle membrane; TAS:Reactome.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005819; C:spindle; IDA:UniProtKB.
 GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
 GO:0005198; F:structural molecule activity; NAS:UniProtKB.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0006886; P:intracellular protein transport; NAS:UniProtKB.
 GO:0007067; P:mitosis; IMP:UniProtKB.
 GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome.
 GO:0031623; P:receptor internalization; IMP:BHF-UCL.
 GO:0033572; P:transferrin transport; IMP:BHF-UCL. 
Interpro
 IPR016024; ARM-type_fold.
 IPR000547; Clathrin_H-chain/VPS_repeat.
 IPR016025; Clathrin_H-chain_link/propller.
 IPR015348; Clathrin_H-chain_linker_core.
 IPR001473; Clathrin_H-chain_propeller_N.
 IPR022365; Clathrin_H-chain_propeller_rpt.
 IPR016341; Clathrin_heavy_chain.
 IPR011990; TPR-like_helical. 
Pfam
 PF00637; Clathrin
 PF09268; Clathrin-link
 PF01394; Clathrin_propel 
SMART
 SM00299; CLH 
PROSITE
 PS50236; CHCR 
PRINTS