CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037948
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Crossover junction endonuclease MUS81 
Protein Synonyms/Alias
  
Gene Name
 MUS81 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
260LDHIVERKRLDDLCSubiquitination[1]
331VKRTADIKESAAYLAubiquitination[1]
414VRGVSGEKAAALVDRubiquitination[1, 2]
449ETLLSTIKCGRLQRNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 476 AA 
Protein Sequence
MLDERLQRHR TSGGDHAPDS PSGENSPAPQ GRLAEVQDSS MPVPAQPKAG GSGSYWPARH 60
SGARVILLVL YREHLNPNGH HFLTKEELLQ RCAQKSPRVA PGSARPWPAL RSLLHRNLVL 120
RTHQPARYSL TPEGLELAQK LAESEGLSLL NVGIGPKEPP GEETAVPGAA SAELASEAGV 180
QQQPLELRPG EYRVLLCVDI GETRGGGHRP ELLRELQRLH VTHTVRKLHV GDFVWVAQET 240
NPRDPANPGE LVLDHIVERK RLDDLCSSII DGRFREQKFR LKRCGLERRV YLVEEHGSVH 300
NLSLPESTLL QAVTNTQVID GFFVKRTADI KESAAYLALL TRGLQRLYQG HTLRSRPWGT 360
PGNPESGAMT SPNPLCSLLT FSDFNAGAIK NKAQSVREVF ARQLMQVRGV SGEKAAALVD 420
RYSTPASLLA AYDACATPKE QETLLSTIKC GRLQRNLGPA LSRTLSQLYC SYGPLT 476 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004518; F:nuclease activity; IEA:InterPro.
 GO:0006281; P:DNA repair; IEA:InterPro.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC. 
Interpro
 IPR020819; DNA_repair_nuc_XPF/helicase.
 IPR006166; ERCC4_domain.
 IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
 IPR011335; Restrct_endonuc-II-like. 
Pfam
 PF02732; ERCC4 
SMART
 SM00891; ERCC4
 SM00278; HhH1 
PROSITE
  
PRINTS