CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000133
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 60 kDa heat shock protein, mitochondrial 
Protein Synonyms/Alias
 60 kDa chaperonin; CPN60; Heat shock protein 60; HSP-60; Hsp60; Mitochondrial matrix protein P1 
Gene Name
 Hsp60 
Gene Synonyms/Alias
 Mmp-P1; CG12101 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
121VLARAIAKEGFEKISacetylation[1]
126IAKEGFEKISKGANPacetylation[1]
129EGFEKISKGANPVEIacetylation[1]
198RDGVITVKDGKTLTDacetylation[1]
355KDDTLLLKGKGKKDDacetylation[1]
383DTTSEYEKEKLQERLacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity). 
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Complete proteome; Direct protein sequencing; Mitochondrion; Nucleotide-binding; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 573 AA 
Protein Sequence
MFRLPVSLAR SSISRQLAMR GYAKDVRFGP EVRAMMLQGV DVLADAVAVT MGPKGRNVII 60
EQSWGSPKIT KDGVTVAKSI ELKDKFQNIG AKLVQDVANN TNEEAGDGTT TATVLARAIA 120
KEGFEKISKG ANPVEIRRGV MLAVETVKDN LKTMSRPVST PEEIAQVATI SANGDQAIGN 180
LISEAMKKVG RDGVITVKDG KTLTDELEVI EGMKFDRGYI SPYFINSSKG AKVEFQDALL 240
LLSEKKISSV QSIIPALELA NAQRKPLVII AEDIDGEALS TLVVNRLKIG LQVAAVKAPG 300
FGDNRKSTLT DMAIASGGIV FGDDADLVKL EDVKVSDLGQ VGEVVITKDD TLLLKGKGKK 360
DDVLRRANQI KDQIEDTTSE YEKEKLQERL ARLASGVALL RVGGSSEVEV NEKKDRVHDA 420
LNATRAAVEE GIVPGGGTAL LRCIEKLEGV ETTNEDQKLG VEIVRRALRM PCMTIAKNAG 480
VDGAMVVAKV ENQAGDYGYD ALKGEYGNLI EKGIIDPTKV VRTAITDASG VASLLTTAEA 540
VVTEIPKEDG APAMPGMGGM GGMGGMGGMG GMM 573 
Gene Ontology
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005743; C:mitochondrial inner membrane; IDA:FlyBase.
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0034605; P:cellular response to heat; IEP:FlyBase.
 GO:0007005; P:mitochondrion organization; IMP:FlyBase.
 GO:0042026; P:protein refolding; IEA:InterPro. 
Interpro
 IPR018370; Chaperonin_Cpn60_CS.
 IPR001844; Chaprnin_Cpn60.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00296; CHAPERONINS_CPN60 
PRINTS
 PR00298; CHAPERONIN60.