CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009415
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial import inner membrane translocase subunit Tim8 B 
Protein Synonyms/Alias
 Deafness dystonia protein 2 homolog 
Gene Name
 Timm8b 
Gene Synonyms/Alias
 Ddp2; Tim8b 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
43CWDKCVEKPGSRLDSacetylation[1]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123
Functional Description
 Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). 
Sequence Annotation
 MOTIF 36 59 Twin CX3C motif.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 DISULFID 36 59 By similarity.
 DISULFID 40 55 By similarity.  
Keyword
 Acetylation; Chaperone; Complete proteome; Disulfide bond; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Protein transport; Reference proteome; Translocation; Transport; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 83 AA 
Protein Sequence
MAELGEADEA ELQRLVAAEQ QKAQFTAQVH HFMELCWDKC VEKPGSRLDS RTENCLSSCV 60
DRFIDTTLAI TGRFAQIVQK GGQ 83 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR004217; Tim10/DDP_fam_Znf. 
Pfam
 PF02953; zf-Tim10_DDP 
SMART
  
PROSITE
  
PRINTS