CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011266
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 rRNA biogenesis protein RRP5 
Protein Synonyms/Alias
 Ribosomal RNA-processing protein 5; U3 small nucleolar RNA-associated protein RRP5; U3 snoRNA-associated protein RRP5 
Gene Name
 RRP5 
Gene Synonyms/Alias
 FMI1; YMR229C; YM9959.11C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
114LIEHVNFKTLKNGSSacetylation[1]
322VNTDFSDKKNKITQIacetylation[1]
379TFSEEDLKHKFVIGSacetylation[1]
769RVFNMSLKSSLIKDAmethylation[2]
807YIKSISDKGLFVAFNacetylation[1]
857RTDDKNQKFLLSLKAacetylation[1]
1101RVLKIAEKYVLLDLGacetylation[1]
1185EIVDGIVKNVNDKGIacetylation[1]
1208EAFVPVSKLSDSYLKacetylation[1]
1449KENVVQDKTIDINTRacetylation[1]
1650GLVADAPKRIDLWNVacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Identification of arginine- and lysine-methylation in the proteome of Saccharomyces cerevisiae and its functional implications.
 Pang CN, Gasteiger E, Wilkins MR.
 BMC Genomics. 2010 Feb 5;11:92. [PMID: 20137074] 
Functional Description
 Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA. 
Sequence Annotation
 DOMAIN 119 200 S1 motif 1.
 DOMAIN 338 410 S1 motif 2.
 DOMAIN 510 580 S1 motif 3.
 DOMAIN 607 676 S1 motif 4.
 DOMAIN 690 769 S1 motif 5.
 DOMAIN 794 863 S1 motif 6.
 DOMAIN 895 971 S1 motif 7.
 DOMAIN 1003 1083 S1 motif 8.
 DOMAIN 1088 1159 S1 motif 9.
 DOMAIN 1177 1245 S1 motif 10.
 DOMAIN 1265 1336 S1 motif 11.
 REPEAT 1455 1487 HAT 1.
 REPEAT 1561 1594 HAT 2.
 REPEAT 1632 1664 HAT 3.
 REPEAT 1666 1701 HAT 4.
 MOD_RES 47 47 Phosphothreonine.
 MOD_RES 187 187 Phosphoserine.
 MOD_RES 188 188 Phosphoserine.
 MOD_RES 1724 1724 Phosphoserine.  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; Ribosome biogenesis; rRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1729 AA 
Protein Sequence
MVASTKRKRD EDFPLSREDS TKQPSTSSLV RNTEEVSFPR GGASALTPLE LKQVANEAAS 60
DVLFGNESVK ASEPASRPLK KKKTTKKSTS KDSEASSANS DEARAGLIEH VNFKTLKNGS 120
SLLGQISAIT KQDLCITFTD GISGYVNLTH ISEEFTSILE DLDEDMDSDT DAADEKKSKV 180
EDAEYESSDD EDEKLDKSNE LPNLRRYFHI GQWLRCSVIK NTSLEPSTKK SKKKRIELTI 240
EPSSVNIYAD EDLVKSTSIQ CAVKSIEDHG ATLDVGLPGF TGFIAKKDFG NFEKLLPGAV 300
FLGNITKKSD RSIVVNTDFS DKKNKITQIS SIDAIIPGQI VDLLCESITK NGIAGKVFGL 360
VSGVVNVSHL RTFSEEDLKH KFVIGSSIRC RIIACLENKS GDKVLILSNL PHILKLEDAL 420
RSTEGLDAFP IGYTFESCSI KGRDSEYLYL ALDDDRLGKV HSSRVGEIEN SENLSSRVLG 480
YSPVDDIYQL STDPKYLKLK YLRTNDIPIG ELLPSCEITS VSSSGIELKI FNGQFKASVP 540
PLHISDTRLV YPERKFKIGS KVKGRVISVN SRGNVHVTLK KSLVNIEDNE LPLVSTYENA 600
KNIKEKNEKT LATIQVFKPN GCIISFFGGL SGFLPNSEIS EVFVKRPEEH LRLGQTVIVK 660
LLDVDADRRR IIATCKVSNE QAAQQKDTIE NIVPGRTIIT VHVIEKTKDS VIVEIPDVGL 720
RGVIYVGHLS DSRIEQNRAQ LKKLRIGTEL TGLVIDKDTR TRVFNMSLKS SLIKDAKKET 780
LPLTYDDVKD LNKDVPMHAY IKSISDKGLF VAFNGKFIGL VLPSYAVDSR DIDISKAFYI 840
NQSVTVYLLR TDDKNQKFLL SLKAPKVKEE KKKVESNIED PVDSSIKSWD DLSIGSIVKA 900
KIKSVKKNQL NVILAANLHG RVDIAEVFDT YEEITDKKQP LSNYKKDDVI KVKIIGNHDV 960
KSHKFLPITH KISKASVLEL SMKPSELKSK EVHTKSLEEI NIGQELTGFV NNSSGNHLWL 1020
TISPVLKARI SLLDLADNDS NFSENIESVF PLGSALQVKV ASIDREHGFV NAIGKSHVDI 1080
NMSTIKVGDE LPGRVLKIAE KYVLLDLGNK VTGISFITDA LNDFSLTLKE AFEDKINNVI 1140
PTTVLSVDEQ NKKIELSLRP ATAKTRSIKS HEDLKQGEIV DGIVKNVNDK GIFVYLSRKV 1200
EAFVPVSKLS DSYLKEWKKF YKPMQYVLGK VVTCDEDSRI SLTLRESEIN GDLKVLKTYS 1260
DIKAGDVFEG TIKSVTDFGV FVKLDNTVNV TGLAHITEIA DKKPEDLSAL FGVGDRVKAI 1320
VLKTNPEKKQ ISLSLKASHF SKEAELASTT TTTTTVDQLE KEDEDEVMAD AGFNDSDSES 1380
DIGDQNTEVA DRKPETSSDG LSLSAGFDWT ASILDQAQEE EESDQDQEDF TENKKHKHKR 1440
RKENVVQDKT IDINTRAPES VADFERLLIG NPNSSVVWMN YMAFQLQLSE IEKARELAER 1500
ALKTINFREE AEKLNIWIAM LNLENTFGTE ETLEEVFSRA CQYMDSYTIH TKLLGIYEIS 1560
EKFDKAAELF KATAKKFGGE KVSIWVSWGD FLISHNEEQE ARTILGNALK ALPKRNHIEV 1620
VRKFAQLEFA KGDPERGRSL FEGLVADAPK RIDLWNVYVD QEVKAKDKKK VEDLFERIIT 1680
KKITRKQAKF FFNKWLQFEE SEGDEKTIEY VKAKATEYVA SHESQKADE 1729 
Gene Ontology
 GO:0030686; C:90S preribosome; IDA:SGD.
 GO:0005730; C:nucleolus; IDA:SGD.
 GO:0032040; C:small-subunit processome; IDA:SGD.
 GO:0008266; F:poly(U) RNA binding; IDA:SGD.
 GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0000464; P:endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. 
Interpro
 IPR003107; HAT.
 IPR012340; NA-bd_OB-fold.
 IPR003029; Rbsml_prot_S1_RNA-bd_dom.
 IPR022967; RNA-binding_domain_S1.
 IPR011990; TPR-like_helical. 
Pfam
 PF00575; S1 
SMART
 SM00386; HAT
 SM00316; S1 
PROSITE
 PS50126; S1 
PRINTS