UniProt Accession

 PRDX2_RAT; P35704; Q6PDV3 

Genbank Protein ID

 U06099; BC058481 

Genbank Nucleotide ID

 AAA19959.1; AAH58481.1 

Protein Name

 Peroxiredoxin-2 

Protein Synonyms/Alias

 Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1 

Gene Name

 Prdx2 

Gene Synonyms/Alias

 Tdpx1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
29	DGAFKEIKLSDYRGK	acetylation	[1]
119	SQNYGVLKNDEGIAY	acetylation	[1]
191	KPNVDDSKEYFSKHN	acetylation	[1]
196	DSKEYFSKHN*****	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). 

Sequence Annotation

 DOMAIN 6 164 Thioredoxin.
 ACT_SITE 51 51 Cysteine sulfenic acid (-SOH)
 MOD_RES 2 2 N-acetylalanine (By similarity).
 DISULFID 51 51 Interchain (with C-172); in linked form
 DISULFID 172 172 Interchain (with C-51); in linked form  

Keyword

 Acetylation; Antioxidant; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Oxidoreductase; Peroxidase; Redox-active center; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 198 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.
 GO:0051920; F:peroxiredoxin activity; IEA:EC.
 GO:0043524; P:negative regulation of neuron apoptotic process; IMP:RGD.
 GO:0019430; P:removal of superoxide radicals; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IMP:RGD. 

Interpro

 IPR000866; AhpC/TSA.
 IPR024706; Peroxiredoxin_AhpC-typ.
 IPR019479; Peroxiredoxin_C.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF10417; 1-cysPrx_C
 PF00578; AhpC-TSA 

SMART

  

PROSITE

 PS51352; THIOREDOXIN_2 

PRINTS