UniProt Accession

 C560_HUMAN; Q99643; O75609; Q3C259; Q3C2D8; Q3C2H4; Q5VTH3 

Genbank Protein ID

 U57877; D49737; AF039594; AF039589; AF039590; AF039591; AF039592; AF039593; AF081495; AB201252; AB211234; AB211235; AB212048; AK294305; AL592295; CH471121; CH471121; BC020808; BC033626; BC066329 

Genbank Nucleotide ID

 AAB41838.1; BAA31998.1; AAC27993.1; AAC27993.1; AAC27993.1; AAC27993.1; AAC27993.1; AAC27993.1; AAC31940.1; BAE46977.1; BAE46978.1; BAE46979.1; BAE46980.1; BAG57586.1; CAH70271.1; EAW52600.1; EAW52604.1; AAH20808.1; AAH33626.1; AAH66329.1 

Protein Name

 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial 

Protein Synonyms/Alias

 Integral membrane protein CII-3; QPs-1; QPs1; Succinate dehydrogenase complex subunit C; Succinate-ubiquinone oxidoreductase cytochrome B large subunit; CYBL 

Gene Name

 SDHC 

Gene Synonyms/Alias

 CYB560; SDH3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
35	VPLGTTAKEEMERFW	ubiquitination	[1, 2]
141	HLMWDLGKGLKIPQL	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). 

Sequence Annotation

 METAL 127 127 Iron (heme axial ligand); shared with  

Keyword

 Alternative splicing; Complete proteome; Electron transport; Heme; Iron; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transit peptide; Transmembrane; Transmembrane helix; Transport; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 169 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; TAS:UniProtKB.
 GO:0005749; C:mitochondrial respiratory chain complex II; ISS:UniProtKB.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0000104; F:succinate dehydrogenase activity; IEA:InterPro.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0006099; P:tricarboxylic acid cycle; TAS:UniProtKB. 

Interpro

 IPR018495; Succ_DH_cyt_bsu_CS.
 IPR014314; Succ_DH_cytb556.
 IPR014361; Succ_DH_cytb560.
 IPR000701; Succ_DH_Fumarate_Rdtase_TM-su. 

Pfam

 PF01127; Sdh_cyt 

SMART

  

PROSITE

 PS01000; SDH_CYT_1
 PS01001; SDH_CYT_2 

PRINTS