UniProt Accession

 APOE_HUMAN; P02649; B2RC15; C0JYY5; Q9P2S4 

Genbank Protein ID

 M12529; K00396; M10065; AF050154; AF261279; AK314898; FJ525876; BC003557; AB035149 

Genbank Nucleotide ID

 AAB59518.1; AAB59546.1; AAB59397.1; AAD02505.1; AAG27089.1; BAG37412.1; ACN81314.1; AAH03557.1; BAA96080.1 

Protein Name

 Apolipoprotein E 

Protein Synonyms/Alias

 Apo-E 

Gene Name

 APOE 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
93	MKELKAYKSELEEQL	glycation	[1]

Reference

 [1] Glycation of apolipoprotein E impairs its binding to heparin: identification of the major glycation site.
 Shuvaev VV, Fujii J, Kawasaki Y, Itoh H, Hamaoka R, Barbier A, Ziegler O, Siest G, Taniguchi N.
 Biochim Biophys Acta. 1999 Aug 30;1454(3):296-308. [PMID: 10452964] 

Functional Description

 Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. 

Sequence Annotation

 REPEAT 80 101 1.
 REPEAT 102 123 2.
 REPEAT 124 145 3.
 REPEAT 146 167 4.
 REPEAT 168 189 5.
 REPEAT 190 211 6.
 REPEAT 212 233 7.
 REPEAT 234 255 8.
 REGION 80 255 8 X 22 AA approximate tandem repeats.
 REGION 158 168 LDL receptor binding (Potential).
 REGION 162 165 Heparin-binding.
 REGION 229 236 Heparin-binding.
 CARBOHYD 26 26 O-linked (GalNAc...).
 CARBOHYD 36 36 O-linked (GalNAc...).
 CARBOHYD 93 93 N-linked (Glc) (glycation).
 CARBOHYD 212 212 O-linked (GalNAc...).
 CARBOHYD 307 307 O-linked (GalNAc...).
 CARBOHYD 308 308 O-linked (GalNAc...).
 CARBOHYD 314 314 O-linked (GalNAc...).  

Keyword

 3D-structure; Alzheimer disease; Amyloidosis; Cholesterol metabolism; Chylomicron; Complete proteome; Direct protein sequencing; Disease mutation; Glycation; Glycoprotein; HDL; Heparin-binding; Hyperlipidemia; Lipid metabolism; Lipid transport; Neurodegeneration; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Steroid metabolism; Sterol metabolism; Transport; VLDL. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 317 AA 

Protein Sequence

Gene Ontology

 GO:0042627; C:chylomicron; IDA:BHF-UCL.
 GO:0030425; C:dendrite; NAS:BHF-UCL.
 GO:0005769; C:early endosome; TAS:Reactome.
 GO:0031232; C:extrinsic to external side of plasma membrane; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0034364; C:high-density lipoprotein particle; IDA:BHF-UCL.
 GO:0034363; C:intermediate-density lipoprotein particle; IDA:BHF-UCL.
 GO:0005770; C:late endosome; IEA:Compara.
 GO:0034362; C:low-density lipoprotein particle; IDA:BHF-UCL.
 GO:0043025; C:neuronal cell body; NAS:BHF-UCL.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL.
 GO:0016209; F:antioxidant activity; IDA:BHF-UCL.
 GO:0001540; F:beta-amyloid binding; IDA:UniProtKB.
 GO:0017127; F:cholesterol transporter activity; IEA:Compara.
 GO:0008201; F:heparin binding; IDA:BHF-UCL.
 GO:0046848; F:hydroxyapatite binding; IEA:Compara.
 GO:0005319; F:lipid transporter activity; IDA:BHF-UCL.
 GO:0071813; F:lipoprotein particle binding; IEA:Compara.
 GO:0050750; F:low-density lipoprotein particle receptor binding; IDA:BHF-UCL.
 GO:0046911; F:metal chelating activity; IDA:BHF-UCL.
 GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IDA:BHF-UCL.
 GO:0005543; F:phospholipid binding; IDA:BHF-UCL.
 GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
 GO:0070326; F:very-low-density lipoprotein particle receptor binding; IDA:BHF-UCL.
 GO:0007568; P:aging; IEA:Compara.
 GO:0048844; P:artery morphogenesis; IEA:Compara.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0071397; P:cellular response to cholesterol; IEA:Compara.
 GO:0071363; P:cellular response to growth factor stimulus; IEA:Compara.
 GO:0071347; P:cellular response to interleukin-1; IEA:Compara.
 GO:0019934; P:cGMP-mediated signaling; IDA:BHF-UCL.
 GO:0006707; P:cholesterol catabolic process; IEA:Compara.
 GO:0033344; P:cholesterol efflux; IDA:BHF-UCL.
 GO:0042632; P:cholesterol homeostasis; IDA:BHF-UCL.
 GO:0008203; P:cholesterol metabolic process; IDA:BHF-UCL.
 GO:0034382; P:chylomicron remnant clearance; IMP:BHF-UCL.
 GO:0007010; P:cytoskeleton organization; TAS:UniProtKB.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:BHF-UCL.
 GO:0034380; P:high-density lipoprotein particle assembly; IDA:BHF-UCL.
 GO:0034384; P:high-density lipoprotein particle clearance; IDA:BHF-UCL.
 GO:0034375; P:high-density lipoprotein particle remodeling; IGI:BHF-UCL.
 GO:0046907; P:intracellular transport; TAS:UniProtKB.
 GO:0042158; P:lipoprotein biosynthetic process; IEA:Compara.
 GO:0042159; P:lipoprotein catabolic process; IEA:Compara.
 GO:0042157; P:lipoprotein metabolic process; TAS:Reactome.
 GO:0034374; P:low-density lipoprotein particle remodeling; IEA:Compara.
 GO:0051651; P:maintenance of location in cell; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IDA:BHF-UCL.
 GO:0043537; P:negative regulation of blood vessel endothelial cell migration; IDA:BHF-UCL.
 GO:0045541; P:negative regulation of cholesterol biosynthetic process; IDA:BHF-UCL.
 GO:0001937; P:negative regulation of endothelial cell proliferation; IDA:BHF-UCL.
 GO:0050728; P:negative regulation of inflammatory response; IC:BHF-UCL.
 GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0010544; P:negative regulation of platelet activation; IDA:BHF-UCL.
 GO:0007263; P:nitric oxide mediated signal transduction; IDA:BHF-UCL.
 GO:0048709; P:oligodendrocyte differentiation; IEA:Compara.
 GO:0014012; P:peripheral nervous system axon regeneration; IEA:Compara.
 GO:0033700; P:phospholipid efflux; IDA:BHF-UCL.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0045773; P:positive regulation of axon extension; IEA:Compara.
 GO:0030828; P:positive regulation of cGMP biosynthetic process; IDA:BHF-UCL.
 GO:0010875; P:positive regulation of cholesterol efflux; IDA:BHF-UCL.
 GO:0010873; P:positive regulation of cholesterol esterification; IDA:BHF-UCL.
 GO:0032805; P:positive regulation of low-density lipoprotein particle receptor catabolic process; IDA:BHF-UCL.
 GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IDA:BHF-UCL.
 GO:0051000; P:positive regulation of nitric-oxide synthase activity; IDA:BHF-UCL.
 GO:0006898; P:receptor-mediated endocytosis; IDA:BHF-UCL.
 GO:0030516; P:regulation of axon extension; TAS:UniProtKB.
 GO:0032489; P:regulation of Cdc42 protein signal transduction; IDA:BHF-UCL.
 GO:0010468; P:regulation of gene expression; IEA:Compara.
 GO:0048168; P:regulation of neuronal synaptic plasticity; TAS:UniProtKB.
 GO:0002021; P:response to dietary excess; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0032868; P:response to insulin stimulus; IEA:Compara.
 GO:0000302; P:response to reactive oxygen species; NAS:UniProtKB.
 GO:0032526; P:response to retinoic acid; IEA:Compara.
 GO:0001523; P:retinoid metabolic process; TAS:Reactome.
 GO:0043691; P:reverse cholesterol transport; IDA:BHF-UCL.
 GO:0007271; P:synaptic transmission, cholinergic; TAS:UniProtKB.
 GO:0006641; P:triglyceride metabolic process; IDA:BHF-UCL.
 GO:0042311; P:vasodilation; IEA:Compara.
 GO:0034447; P:very-low-density lipoprotein particle clearance; IDA:BHF-UCL.
 GO:0034372; P:very-low-density lipoprotein particle remodeling; IDA:BHF-UCL. 

Interpro

 IPR013326; ApoA.
 IPR000074; ApoA1_A4_E. 

Pfam

 PF01442; Apolipoprotein 

SMART

  

PROSITE

  

PRINTS