CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035780
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hect (Homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2 (Predicted) 
Protein Synonyms/Alias
 Protein Herc2 
Gene Name
 Herc2 
Gene Synonyms/Alias
 Herc2_predicted; rCG_45123 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
934RSRTPLDKDLINTGIubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ligase; Reference proteome; Repeat; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4779 AA 
Protein Sequence
MVENRYPDDG VDAQSGTKKE DLNDKEKKEE EETPAPVCRA KSILESWVWG RQPDVNELKE 60
CLSVLVKEQQ ALAVQSATTT LSALRLKQRL VILERYFIAL NRTVFQENVK VKWKSSSISV 120
PPTEKKSARP PGRGVEGLAR VGSRAALSFA FAFLRRAWRS GEDADLCSEL LQESLDALRA 180
LPEASLFDES TVSSVWLEVV ERATRFLRSV VTGDVHGTPG TKGPGGVPLQ DQHLALAILL 240
ELAVQRGTLS QMLSAILLLL QLWDSGAQET DNERSAQGTS APLLPLLHRF QSILCSKDMP 300
HTESDMHLLS GPLSPNESFL KYLTLPQDNE LAIDLRQTAV VVMAHLDRLA TPCMPPLCSS 360
PTSHKGSLQE VIGWGLIGWK YYANVIGPIQ CEGLASLGVM QVACAEKRFL ILSRNGRVYT 420
QAYNSDMLAP QLVQGLASRN IVKIAAHSDG HHYLALAATG EVYSWGCGDG GRLGHGDTVP 480
LEEPKVISAF SGKQAGKHVV HIACGSTYSA AITAEGELYT WGRGNYGRLG HGSSEDEAIP 540
MLVAGLKGLK VIDVACGSGD AQTLAVTENG QVWSWGDGDY GKLGRGGSDG CKTPKLIEKL 600
QDLDVIKVRC GSQFSIALTK DGQVYSWGKG DNQRLGHGTE EHVRYPKLLE GLQGKKVIDV 660
AAGSTHCLAL TEDSEVHSWG SNDQCQHFDT LRVTKPEPTA LPGLDTKHIV GIACGPAQSF 720
AWSSCSEWSI GLRVPFVVDI CPVTFEQLDL LLRQVSEGMD GTADWPPPQE KECMAVATLN 780
LLRLQLHAAI SHQVDPEFLG LGLGSVLLNS LKQTVVTLAS SAGVLSTVQS AAQAVLQSGW 840
SVLLPTAEER ARALSALLPC TGNEVNISPG RRFMIDLLVG SLMADGGLES ALNAAITAEI 900
QDIEAKKEAQ KEKEIDEQEA NASTFHRSRT PLDKDLINTG IYESSGKQCL PLVQLIQQLL 960
RNIASQTVAR LKDVARRISS CLDFEQHSCE RSASLDLLLR FQRLLISKLY PGENIGPISD 1020
TSSPELMGVG SLLKKYTALV CTHIGDILPV AASIASSSWQ HFAEVACVME GDFTGVLLPE 1080
LVVSIVLLLS KNASLMQEAG AIPLLGGLLE HLDRFNHLAP GKERDDHEEL AWPGIMESFF 1140
TGQNCRNNEE VTLIRKADLE NHNKDGGFWT VIDGKVYDIK DFQTQSLTGN SILAQFAGED 1200
PVVALEAALQ FEDTQESMHA FCVGQYLEPD QEVVTIPDLG SLSSPLIDTE RNLGLLLGLH 1260
ASYLAMSTPL SPVEVECAKW LQSSIFSGGL QTSQIHYSYN EEKDEDHCSS PGGTPISKSR 1320
LCSHRWALGD HSQAFLQAIA DNNIQDYNVK DFLCQIERYC RQCHLTTPIT FPPEHPVEEV 1380
GRLLLCCLLK HEDLGHVALS LVHVGTLGIE QVKHRALPKA VVDVCRVVYQ AKCSLIKTHQ 1440
EQGRSYKEVC APVIERLRFL FNELRPAVCS DLSIMSKFKL LGSLPRWRRI AQKIIRERRR 1500
KRVPKKPEST DGEEKIGNEE SDLEEACVLP HSPINVDKRP ISMKSPKDKW QPLLNTVTGV 1560
HKYKWLKQNV QGLYPQSALL NTIVEFALKE EPVDVEKMRK CLLKQLERAE VRLEGIDTIL 1620
KLAAKSFLLP SVQYAMFCGW QRLIPEGIDI GEPLTDCLRD VDLIPPFNRM LLEVTFGKLY 1680
AWAVQNIRSV LMDASAKFKE LGIQPVPLQT ITNENPAGPS LGTIPQARFL LVMLSMLTLQ 1740
HGANNLDLLL NSGTLALTQT ALKLIGPTCD SVEDDMNASA RGASATVLEE TRKETAPVQL 1800
PVSGPELAAM MKIGTRVMRG VDWKWGDQDG PPPGLGRVIG ELGEDGWIRV QWDTGSTNSY 1860
RMGKEGKYDL KLVELPVSSQ PSAEDSDTED DSEAEQGERN IHPTAMMLTS VINLLQTLCL 1920
SVGVHADIMQ SEATKTLCGL LRMLVESGTT DKPSPPDRLV AREQHRSWCT LGFVRSIALT 1980
PQACGALSSP RWITLLMKVV EGHAPFTAAS LQRQILAVHL LQAVLPSWDK TERARDMKCL 2040
VEKLFGFLGS LLTTCSSDVP LLRESTLRKR RARPQASLTA THSSTLAEEV VGLLRTLHSL 2100
TQWNGLINKY INSQLCSVTQ SYAGKTSERT LLEDYFPDSE NLEVGGLMAV LAVIGGIDGR 2160
LRLGGQVMHD EFGEGTVTRI TPKGKITVQF CDMRMCRVCP LNQLKPLPAV AFSVNNLPFT 2220
EPMLSVWAEL VNLAGSKLEK HKTKKSAKQA FAGQVDLDLL RSQQLKLYIL KAGRALLSHQ 2280
DKLRQILSQP AVQETGTLHT DDGAAASPDL GDMSPEGPQP PMILLQQLLS SATQPSPVKA 2340
IFDKQELEAA ALALCQCLAV ESTHPSSPGC EDCSSSEATT PVSVQHIHLA RAKKHRQSPA 2400
PALPIVVQLM EMGFPRKNIE FALKSLTGTS GNASGLPGVE ALVGWLLDHS DVQVTEFSDA 2460
ETVSDEYSDE EVVEDVDDTP YPVAAGAVVT ESQTYKKRAD FLSNDDYAVY VRENVQVGMM 2520
VRCCRTYEEV CEGDVGKVIK LDRDGLHDLN VQCDWQQKGG TYWVRYIHVE LIGYPPPSSS 2580
SHIKIGDKVR VKASVTTPKY KWGSVTHQSV GLVKAFSANG KDIIVDFPQQ SHWTGLLSEM 2640
ELVPSIHPGV TCDGCQTFPI NGSRFKCRNC DDFDFCETCF KTKKHNTRHT FGRINEPGQS 2700
AVFCGRSGKQ LKRCHSSQPG MLLDSWSRMV KSLNVSSSVN QASRLIDGSE PCWQSSGSQG 2760
KHWIRLEIFP DVLVHRLKMI VDPADSSYMP SLVVVSGGNS LNNLIELKTI NINQTDTTVP 2820
LLSDCAEYHR YIEIAIKQCR SSGIDCKIHG LILLGRIRAE EEDLAAVPFL ASDNEEEEDD 2880
KGSTGSLIRK KTPGLESTAT IRTKVFVWGL NDKDQLGGLK GSKIKVPSFS ETLSALNVVQ 2940
VAGGSKSLFA VTVEGKVYSC GEATNGRLGL GMSSGTVPIP RQITALSSYV VKKVAVHSGG 3000
RHATALTVDG KVFSWGEGDD GKLGHFSRMN CDKPRLIEAL KTKRIRDIAC GSSHSAALTS 3060
SGELYTWGLG EYGRLGHGDN TTQLKPKMVK VLLGHRVIQV ACGSRDAQTL ALTDEGLVFS 3120
WGDGDFGKLG RGGSEGCNIP QNIERLNGQG VCQIECGAQF SLALTKSGVV WTWGKGDYFR 3180
LGHGSDVHVR KPQVVEGLRG KKIVHVAVGA LHCLAVTDSG QVYAWGDNDH GQQGNGTTTV 3240
NRKPTLVQGL EGQKITRVAC GSSHSVAWTT VDVATPSVHE PVLFQTARDP LGASYLGVPS 3300
DADSSSSSNK ISGVSNCKPN RPSLAKILLS LEGNLAKQQA LSHILTALQI MYARDAVVGA 3360
LMPAGMLAPV ECPSFSSSAP ASDVSAMASP MNVEESMLAA DLEDRLSPNL WQEKREIVSS 3420
EDAVTPSAVT PSAPSASSRP FIPVTDDPGA ASIIAETMTK TKEDVESQNK TSGPEPQSLD 3480
EFTSLLIPDD TRVVVDLLKL SVCSRAGDRG REVLSAVLSG MGIAYPQVAD MLLELCVTEL 3540
EDVATDSQSG RLSSQPVVVE SSHPYTDDTS TSGTVKIPGA EGLRVEFDRQ CSTERRHDPL 3600
TVMDGVNRIV SVRSGREWSD WSSELRIPGD ELKWKFISDG SVNGWGWRFT VYPIMPAAGP 3660
KDLLSDRCVL SCPSMDLVTC LLDFRLNLTS NRSIVPRLAA SLAACAQLSA LAASHRMWAL 3720
QRLRRLLTTE FGQSININRL LGENDGETRA LSFTGSALAA LVKGLPEALQ RQFEYEDPIV 3780
RGGKQLLHSP FFKVLVALAC DLELDTLPCC AETHKWAWFR RYCMASRVAV ALDKRTPLPR 3840
LFLDEVAKKI RELMADSESM DVLHESHSIF KREQDEQLVQ WMNRRPDDWT LSAGGSGTIY 3900
GWGHNHRGQL GGIEGAKVKV PTPCEALATL RPVQLIGGEQ TLFAVTADGK LYATGYGAGG 3960
RLGIGGTESV STPTLLESIQ HVFIKKVAVN SGGKHCLALS SEGEVYSWGE AEDGKLGHGN 4020
RSPCDRPRVI ESLRGIEVVD VAAGGAHSAC VTAAGDLYTW GKGRYGRLGH SDSEDQLKPK 4080
LVEALQGHRV IDIACGSGDA QTLCLTDDDT VWSWGDGDYG KLGRGGSDGC KVPMKIDSLT 4140
GLGVVKVECG SQFSVALTKS GAVYTWGKGD YHRLGHGSDD HVRRPRQVQG LQGKKVIAIA 4200
TGSLHCVCCT EDGEVYTWGD NDEGQLGDGT TNAIQRPRLV AALQGKKVNR VACGSAHTLA 4260
WSTSKPASAG KLPAQVPMEY NHLQEIPIIA LRNRLLLLHH ISELFCPCIP MFDLEGSLDE 4320
TGLGPSVGFD TLRGILISQG KEAAFRKVVQ ATMVRDRQHG PVVELNRIQV KRSRSKGGLA 4380
GPDGTKSVFG QMCAKMSSFS PDSLLLPHRV WKVKFVGESV DDCGGGYSES IAEICEELQN 4440
GLTPLLIVTP NGRDESGANR DCYLLNPATR APVHCSMFRF LGVLLGIAIR TGSPLSLNLA 4500
EPVWKQLAGM SLTIADLSEV DKDFIPGLMY IRDNEATSEE FEAMSLPFTV PSASGQDIQL 4560
SSKHTHITLD NRAEYVRLAI NYRLHEFDEQ VAAVREGMAR VVPVPLLSLF TGYELETMVC 4620
GSPDIPLHLL KSVATYKGIE PSASLVQWFW EVMESFSNTE RSLFLRFVWG RTRLPRTIAD 4680
FRGRDFVIQV LDKYNPPDHF LPESYTCFFL LKLPRYSCKQ VLEEKLKYAI HFCKSIDTDD 4740
YARIALTGEP AADDSSEDSD NEDADSFASD STQDYLTGH 4779 
Gene Ontology
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. 
Interpro
 IPR004939; APC_su10/DOC_dom.
 IPR006624; Beta-propeller_rpt_TECPR.
 IPR021097; CPH_domain.
 IPR001199; Cyt_B5-like_heme/steroid-bd.
 IPR008979; Galactose-bd-like.
 IPR000569; HECT.
 IPR010606; Mib_Herc2.
 IPR009091; RCC1/BLIP-II.
 IPR000408; Reg_chr_condens.
 IPR014722; Rib_L2_dom2.
 IPR000433; Znf_ZZ. 
Pfam
 PF03256; APC10
 PF11515; Cul7
 PF00173; Cyt-b5
 PF00632; HECT
 PF06701; MIB_HERC2
 PF00415; RCC1
 PF00569; ZZ 
SMART
 SM00119; HECTc
 SM00706; TECPR
 SM00291; ZnF_ZZ 
PROSITE
 PS50255; CYTOCHROME_B5_2
 PS51284; DOC
 PS50237; HECT
 PS51416; MIB_HERC2
 PS00626; RCC1_2
 PS50012; RCC1_3
 PS01357; ZF_ZZ_1
 PS50135; ZF_ZZ_2 
PRINTS
 PR00633; RCCNDNSATION.