Tag | Content |
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CPLM ID | CPLM-035780 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Hect (Homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2 (Predicted) |
Protein Synonyms/Alias | Protein Herc2 |
Gene Name | Herc2 |
Gene Synonyms/Alias | Herc2_predicted; rCG_45123 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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934 | RSRTPLDKDLINTGI | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | |
Sequence Annotation | |
Keyword | Complete proteome; Ligase; Reference proteome; Repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 4779 AA |
Protein Sequence | MVENRYPDDG VDAQSGTKKE DLNDKEKKEE EETPAPVCRA KSILESWVWG RQPDVNELKE 60 CLSVLVKEQQ ALAVQSATTT LSALRLKQRL VILERYFIAL NRTVFQENVK VKWKSSSISV 120 PPTEKKSARP PGRGVEGLAR VGSRAALSFA FAFLRRAWRS GEDADLCSEL LQESLDALRA 180 LPEASLFDES TVSSVWLEVV ERATRFLRSV VTGDVHGTPG TKGPGGVPLQ DQHLALAILL 240 ELAVQRGTLS QMLSAILLLL QLWDSGAQET DNERSAQGTS APLLPLLHRF QSILCSKDMP 300 HTESDMHLLS GPLSPNESFL KYLTLPQDNE LAIDLRQTAV VVMAHLDRLA TPCMPPLCSS 360 PTSHKGSLQE VIGWGLIGWK YYANVIGPIQ CEGLASLGVM QVACAEKRFL ILSRNGRVYT 420 QAYNSDMLAP QLVQGLASRN IVKIAAHSDG HHYLALAATG EVYSWGCGDG GRLGHGDTVP 480 LEEPKVISAF SGKQAGKHVV HIACGSTYSA AITAEGELYT WGRGNYGRLG HGSSEDEAIP 540 MLVAGLKGLK VIDVACGSGD AQTLAVTENG QVWSWGDGDY GKLGRGGSDG CKTPKLIEKL 600 QDLDVIKVRC GSQFSIALTK DGQVYSWGKG DNQRLGHGTE EHVRYPKLLE GLQGKKVIDV 660 AAGSTHCLAL TEDSEVHSWG SNDQCQHFDT LRVTKPEPTA LPGLDTKHIV GIACGPAQSF 720 AWSSCSEWSI GLRVPFVVDI CPVTFEQLDL LLRQVSEGMD GTADWPPPQE KECMAVATLN 780 LLRLQLHAAI SHQVDPEFLG LGLGSVLLNS LKQTVVTLAS SAGVLSTVQS AAQAVLQSGW 840 SVLLPTAEER ARALSALLPC TGNEVNISPG RRFMIDLLVG SLMADGGLES ALNAAITAEI 900 QDIEAKKEAQ KEKEIDEQEA NASTFHRSRT PLDKDLINTG IYESSGKQCL PLVQLIQQLL 960 RNIASQTVAR LKDVARRISS CLDFEQHSCE RSASLDLLLR FQRLLISKLY PGENIGPISD 1020 TSSPELMGVG SLLKKYTALV CTHIGDILPV AASIASSSWQ HFAEVACVME GDFTGVLLPE 1080 LVVSIVLLLS KNASLMQEAG AIPLLGGLLE HLDRFNHLAP GKERDDHEEL AWPGIMESFF 1140 TGQNCRNNEE VTLIRKADLE NHNKDGGFWT VIDGKVYDIK DFQTQSLTGN SILAQFAGED 1200 PVVALEAALQ FEDTQESMHA FCVGQYLEPD QEVVTIPDLG SLSSPLIDTE RNLGLLLGLH 1260 ASYLAMSTPL SPVEVECAKW LQSSIFSGGL QTSQIHYSYN EEKDEDHCSS PGGTPISKSR 1320 LCSHRWALGD HSQAFLQAIA DNNIQDYNVK DFLCQIERYC RQCHLTTPIT FPPEHPVEEV 1380 GRLLLCCLLK HEDLGHVALS LVHVGTLGIE QVKHRALPKA VVDVCRVVYQ AKCSLIKTHQ 1440 EQGRSYKEVC APVIERLRFL FNELRPAVCS DLSIMSKFKL LGSLPRWRRI AQKIIRERRR 1500 KRVPKKPEST DGEEKIGNEE SDLEEACVLP HSPINVDKRP ISMKSPKDKW QPLLNTVTGV 1560 HKYKWLKQNV QGLYPQSALL NTIVEFALKE EPVDVEKMRK CLLKQLERAE VRLEGIDTIL 1620 KLAAKSFLLP SVQYAMFCGW QRLIPEGIDI GEPLTDCLRD VDLIPPFNRM LLEVTFGKLY 1680 AWAVQNIRSV LMDASAKFKE LGIQPVPLQT ITNENPAGPS LGTIPQARFL LVMLSMLTLQ 1740 HGANNLDLLL NSGTLALTQT ALKLIGPTCD SVEDDMNASA RGASATVLEE TRKETAPVQL 1800 PVSGPELAAM MKIGTRVMRG VDWKWGDQDG PPPGLGRVIG ELGEDGWIRV QWDTGSTNSY 1860 RMGKEGKYDL KLVELPVSSQ PSAEDSDTED DSEAEQGERN IHPTAMMLTS VINLLQTLCL 1920 SVGVHADIMQ SEATKTLCGL LRMLVESGTT DKPSPPDRLV AREQHRSWCT LGFVRSIALT 1980 PQACGALSSP RWITLLMKVV EGHAPFTAAS LQRQILAVHL LQAVLPSWDK TERARDMKCL 2040 VEKLFGFLGS LLTTCSSDVP LLRESTLRKR RARPQASLTA THSSTLAEEV VGLLRTLHSL 2100 TQWNGLINKY INSQLCSVTQ SYAGKTSERT LLEDYFPDSE NLEVGGLMAV LAVIGGIDGR 2160 LRLGGQVMHD EFGEGTVTRI TPKGKITVQF CDMRMCRVCP LNQLKPLPAV AFSVNNLPFT 2220 EPMLSVWAEL VNLAGSKLEK HKTKKSAKQA FAGQVDLDLL RSQQLKLYIL KAGRALLSHQ 2280 DKLRQILSQP AVQETGTLHT DDGAAASPDL GDMSPEGPQP PMILLQQLLS SATQPSPVKA 2340 IFDKQELEAA ALALCQCLAV ESTHPSSPGC EDCSSSEATT PVSVQHIHLA RAKKHRQSPA 2400 PALPIVVQLM EMGFPRKNIE FALKSLTGTS GNASGLPGVE ALVGWLLDHS DVQVTEFSDA 2460 ETVSDEYSDE EVVEDVDDTP YPVAAGAVVT ESQTYKKRAD FLSNDDYAVY VRENVQVGMM 2520 VRCCRTYEEV CEGDVGKVIK LDRDGLHDLN VQCDWQQKGG TYWVRYIHVE LIGYPPPSSS 2580 SHIKIGDKVR VKASVTTPKY KWGSVTHQSV GLVKAFSANG KDIIVDFPQQ SHWTGLLSEM 2640 ELVPSIHPGV TCDGCQTFPI NGSRFKCRNC DDFDFCETCF KTKKHNTRHT FGRINEPGQS 2700 AVFCGRSGKQ LKRCHSSQPG MLLDSWSRMV KSLNVSSSVN QASRLIDGSE PCWQSSGSQG 2760 KHWIRLEIFP DVLVHRLKMI VDPADSSYMP SLVVVSGGNS LNNLIELKTI NINQTDTTVP 2820 LLSDCAEYHR YIEIAIKQCR SSGIDCKIHG LILLGRIRAE EEDLAAVPFL ASDNEEEEDD 2880 KGSTGSLIRK KTPGLESTAT IRTKVFVWGL NDKDQLGGLK GSKIKVPSFS ETLSALNVVQ 2940 VAGGSKSLFA VTVEGKVYSC GEATNGRLGL GMSSGTVPIP RQITALSSYV VKKVAVHSGG 3000 RHATALTVDG KVFSWGEGDD GKLGHFSRMN CDKPRLIEAL KTKRIRDIAC GSSHSAALTS 3060 SGELYTWGLG EYGRLGHGDN TTQLKPKMVK VLLGHRVIQV ACGSRDAQTL ALTDEGLVFS 3120 WGDGDFGKLG RGGSEGCNIP QNIERLNGQG VCQIECGAQF SLALTKSGVV WTWGKGDYFR 3180 LGHGSDVHVR KPQVVEGLRG KKIVHVAVGA LHCLAVTDSG QVYAWGDNDH GQQGNGTTTV 3240 NRKPTLVQGL EGQKITRVAC GSSHSVAWTT VDVATPSVHE PVLFQTARDP LGASYLGVPS 3300 DADSSSSSNK ISGVSNCKPN RPSLAKILLS LEGNLAKQQA LSHILTALQI MYARDAVVGA 3360 LMPAGMLAPV ECPSFSSSAP ASDVSAMASP MNVEESMLAA DLEDRLSPNL WQEKREIVSS 3420 EDAVTPSAVT PSAPSASSRP FIPVTDDPGA ASIIAETMTK TKEDVESQNK TSGPEPQSLD 3480 EFTSLLIPDD TRVVVDLLKL SVCSRAGDRG REVLSAVLSG MGIAYPQVAD MLLELCVTEL 3540 EDVATDSQSG RLSSQPVVVE SSHPYTDDTS TSGTVKIPGA EGLRVEFDRQ CSTERRHDPL 3600 TVMDGVNRIV SVRSGREWSD WSSELRIPGD ELKWKFISDG SVNGWGWRFT VYPIMPAAGP 3660 KDLLSDRCVL SCPSMDLVTC LLDFRLNLTS NRSIVPRLAA SLAACAQLSA LAASHRMWAL 3720 QRLRRLLTTE FGQSININRL LGENDGETRA LSFTGSALAA LVKGLPEALQ RQFEYEDPIV 3780 RGGKQLLHSP FFKVLVALAC DLELDTLPCC AETHKWAWFR RYCMASRVAV ALDKRTPLPR 3840 LFLDEVAKKI RELMADSESM DVLHESHSIF KREQDEQLVQ WMNRRPDDWT LSAGGSGTIY 3900 GWGHNHRGQL GGIEGAKVKV PTPCEALATL RPVQLIGGEQ TLFAVTADGK LYATGYGAGG 3960 RLGIGGTESV STPTLLESIQ HVFIKKVAVN SGGKHCLALS SEGEVYSWGE AEDGKLGHGN 4020 RSPCDRPRVI ESLRGIEVVD VAAGGAHSAC VTAAGDLYTW GKGRYGRLGH SDSEDQLKPK 4080 LVEALQGHRV IDIACGSGDA QTLCLTDDDT VWSWGDGDYG KLGRGGSDGC KVPMKIDSLT 4140 GLGVVKVECG SQFSVALTKS GAVYTWGKGD YHRLGHGSDD HVRRPRQVQG LQGKKVIAIA 4200 TGSLHCVCCT EDGEVYTWGD NDEGQLGDGT TNAIQRPRLV AALQGKKVNR VACGSAHTLA 4260 WSTSKPASAG KLPAQVPMEY NHLQEIPIIA LRNRLLLLHH ISELFCPCIP MFDLEGSLDE 4320 TGLGPSVGFD TLRGILISQG KEAAFRKVVQ ATMVRDRQHG PVVELNRIQV KRSRSKGGLA 4380 GPDGTKSVFG QMCAKMSSFS PDSLLLPHRV WKVKFVGESV DDCGGGYSES IAEICEELQN 4440 GLTPLLIVTP NGRDESGANR DCYLLNPATR APVHCSMFRF LGVLLGIAIR TGSPLSLNLA 4500 EPVWKQLAGM SLTIADLSEV DKDFIPGLMY IRDNEATSEE FEAMSLPFTV PSASGQDIQL 4560 SSKHTHITLD NRAEYVRLAI NYRLHEFDEQ VAAVREGMAR VVPVPLLSLF TGYELETMVC 4620 GSPDIPLHLL KSVATYKGIE PSASLVQWFW EVMESFSNTE RSLFLRFVWG RTRLPRTIAD 4680 FRGRDFVIQV LDKYNPPDHF LPESYTCFFL LKLPRYSCKQ VLEEKLKYAI HFCKSIDTDD 4740 YARIALTGEP AADDSSEDSD NEDADSFASD STQDYLTGH 4779 |
Gene Ontology | GO:0005737; C:cytoplasm; IBA:RefGenome. GO:0005634; C:nucleus; IBA:RefGenome. GO:0020037; F:heme binding; IEA:InterPro. GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |