| Tag | Content |
|---|
| CPLM ID | CPLM-012248 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tripartite motif-containing protein 29 |
Protein Synonyms/Alias | Ataxia telangiectasia group D-associated protein |
Gene Name | TRIM29 |
Gene Synonyms/Alias | ATDC |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 102 | SMDSMEGKRSPYAGL | acetylation | [1] | | 116 | LQLGAAKKPPVTFAE | acetylation | [1] | | 275 | ETELSLQKEQLQLKI | acetylation | [1] | | 291 | EIEDEAEKWQKEKDR | acetylation | [1] | | 300 | QKEKDRIKSFTTNEK | acetylation | [1] | | 361 | AKVLHEDKQTREQLH | acetylation | [1] | | 478 | YSMYLTPKGGVRTSY | acetylation | [1] | | 495 | SSPGRFTKETTQKNF | acetylation | [1] | | 554 | LMRSQSPKAQPQTWK | acetylation | [1] |
|
Reference | [1] The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions. Yuan Z, Villagra A, Peng L, Coppola D, Glozak M, Sotomayor EM, Chen J, Lane WS, Seto E. Mol Cell Biol. 2010 Jun;30(12):3004-15. [ PMID: 20368352] |
Functional Description | It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line. |
Sequence Annotation | ZN_FING 220 260 B box-type.
MOD_RES 9 9 Phosphoserine (By similarity).
MOD_RES 13 13 Phosphoserine (By similarity).
MOD_RES 21 21 Phosphoserine.
MOD_RES 104 104 Phosphoserine.
MOD_RES 476 476 Phosphothreonine.
MOD_RES 489 489 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 588 AA |
Protein Sequence | MEAADASRSN GSSPEARDAR SPSGPSGSLE NGTKADGKDA KTTNGHGGEA AEGKSLGSAL 60
KPGEGRSALF AGNEWRRPII QFVESGDDKN SNYFSMDSME GKRSPYAGLQ LGAAKKPPVT 120
FAEKGELRKS IFSESRKPTV SIMEPGETRR NSYPRADTGL FSRSKSGSEE VLCDSCIGNK 180
QKAVKSCLVC QASFCELHLK PHLEGAAFRD HQLLEPIRDF EARKCPVHGK TMELFCQTDQ 240
TCICYLCMFQ EHKNHSTVTV EEAKAEKETE LSLQKEQLQL KIIEIEDEAE KWQKEKDRIK 300
SFTTNEKAIL EQNFRDLVRD LEKQKEEVRA ALEQREQDAV DQVKVIMDAL DERAKVLHED 360
KQTREQLHSI SDSVLFLQEF GALMSNYSLP PPLPTYHVLL EGEGLGQSLG NFKDDLLNVC 420
MRHVEKMCKA DLSRNFIERN HMENGGDHRY VNNYTNSFGG EWSAPDTMKR YSMYLTPKGG 480
VRTSYQPSSP GRFTKETTQK NFNNLYGTKG NYTSRVWEYS SSIQNSDNDL PVVQGSSSFS 540
LKGYPSLMRS QSPKAQPQTW KSGKQTMLSH YRPFYVNKGN GIGSNEAP 588 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:1900181; P:negative regulation of protein localization to nucleus; IEA:Compara. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |