CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017044
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bardet-Biedl syndrome 7 protein 
Protein Synonyms/Alias
 BBS2-like protein 1 
Gene Name
 BBS7 
Gene Synonyms/Alias
 BBS2L1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
19QVGVTSQKTMKLIPAubiquitination[1]
22VTSQKTMKLIPASRHubiquitination[2]
51VMCFGMKKGEAAAVFubiquitination[1, 2]
59GEAAAVFKTLPGPKIubiquitination[2]
225LIQITTSKPVRKWEIubiquitination[2]
333SGPGEELKINQEMQNubiquitination[1, 2, 3]
341INQEMQNKISSLRNEubiquitination[1, 2]
355ELEHLQYKVLQERENubiquitination[1, 2, 4, 5]
457DTTRLELKIRSIEGQubiquitination[2]
479VTPRIQPKTCQVRQYubiquitination[2]
489QVRQYHIKPLSLHQRubiquitination[2]
577ISTISILKDVLSKEAubiquitination[1, 2, 3]
582ILKDVLSKEATKRKIubiquitination[1]
622YQLLLAKKVQLIDALubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. 
Sequence Annotation
  
Keyword
 Alternative splicing; Bardet-Biedl syndrome; Cell membrane; Cell projection; Ciliopathy; Cilium; Complete proteome; Cytoplasm; Disease mutation; Membrane; Mental retardation; Obesity; Polymorphism; Reference proteome; Sensory transduction; Vision. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 715 AA 
Protein Sequence
MDLILNRMDY LQVGVTSQKT MKLIPASRHR ATQKVVIGDH DGVVMCFGMK KGEAAAVFKT 60
LPGPKIARLE LGGVINTPQE KIFIAAASEI RGFTKRGKQF LSFETNLTES IKAMHISGSD 120
LFLSASYIYN HYCDCKDQHY YLSGDKINDV ICLPVERLSR ITPVLACQDR VLRVLQGSDV 180
MYAVEVPGPP TVLALHNGNG GDSGEDLLFG TSDGKLALIQ ITTSKPVRKW EIQNEKKRGG 240
ILCIDSFDIV GDGVKDLLVG RDDGMVEVYS FDNANEPVLR FDQMLSESVT SIQGGCVGKD 300
SYDEIVVSTY SGWVTGLTTE PIHKESGPGE ELKINQEMQN KISSLRNELE HLQYKVLQER 360
ENYQQSSQSS KAKSAVPSFG INDKFTLNKD DASYSLILEV QTAIDNVLIQ SDVPIDLLDV 420
DKNSAVVSFS SCDSESNDNF LLATYRCQAD TTRLELKIRS IEGQYGTLQA YVTPRIQPKT 480
CQVRQYHIKP LSLHQRTHFI DHDRPMNTLT LTGQFSFAEV HSWVVFCLPE VPEKPPAGEC 540
VTFYFQNTFL DTQLESTYRK GEGVFKSDNI STISILKDVL SKEATKRKIN LNISYEINEV 600
SVKHTLKLIH PKLEYQLLLA KKVQLIDALK ELQIHEGNTN FLIPEYHCIL EEADHLQEEY 660
KKQPAHLERL YGMITDLFID KFKFKGTNVK TKVPLLLEIL DSYDQNALIS FFDAA 715 
Gene Ontology
 GO:0034464; C:BBSome; IDA:BHF-UCL.
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0060170; C:cilium membrane; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0060271; P:cilium morphogenesis; ISS:BHF-UCL.
 GO:0048546; P:digestive tract morphogenesis; ISS:BHF-UCL.
 GO:0045444; P:fat cell differentiation; ISS:BHF-UCL.
 GO:0001947; P:heart looping; ISS:BHF-UCL.
 GO:0032402; P:melanosome transport; ISS:BHF-UCL.
 GO:0051877; P:pigment granule aggregation in cell center; ISS:BHF-UCL.
 GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
 GO:0007601; P:visual perception; IEA:UniProtKB-KW. 
Interpro
 IPR016575; Bardet-Biedl_syndrome_7_prot.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR017986; WD40_repeat_dom. 
Pfam
  
SMART
  
PROSITE
  
PRINTS