UniProt Accession

 NUD12_MOUSE; Q9DCN1; Q6PFA5 

Genbank Protein ID

 AK002641; BC057657 

Genbank Nucleotide ID

 BAB22253.1; AAH57657.1 

Protein Name

 Peroxisomal NADH pyrophosphatase NUDT12 

Protein Synonyms/Alias

 Nucleoside diphosphate-linked moiety X motif 12; Nudix motif 12 

Gene Name

 Nudt12 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
10	SVKRNPKKEMISELH	acetylation	[1]
10	SVKRNPKKEMISELH	succinylation	[1]
185	QLNYPDVKGYLAQPE	acetylation	[1]
185	QLNYPDVKGYLAQPE	succinylation	[1]
282	LAWHSRYKFCPTCGS	acetylation	[2]
292	PTCGSATKIEEGGYK	acetylation	[1]
292	PTCGSATKIEEGGYK	succinylation	[1]
453	AIAHQLIKHWVGMNP	acetylation	[3]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (By similarity). 

Sequence Annotation

 REPEAT 11 40 ANK 1.
 REPEAT 45 74 ANK 2.
 REPEAT 78 98 ANK 3.
 DOMAIN 319 453 Nudix hydrolase.
 MOTIF 355 376 Nudix box.
 MOTIF 460 462 Microbody targeting signal (By
 METAL 370 370 Magnesium or manganese (By similarity).
 METAL 374 374 Magnesium or manganese (By similarity).  

Keyword

 Alternative splicing; ANK repeat; Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; NAD; NADP; Peroxisome; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 462 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005777; C:peroxisome; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0000210; F:NAD+ diphosphatase activity; IDA:MGI.
 GO:0035529; F:NADH pyrophosphatase activity; IDA:MGI.
 GO:0019677; P:NAD catabolic process; IDA:MGI.
 GO:0006742; P:NADP catabolic process; IDA:MGI. 

Interpro

 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR015375; NADH_PPase-like_N.
 IPR020084; NUDIX_hydrolase_CS.
 IPR000086; NUDIX_hydrolase_dom.
 IPR015797; NUDIX_hydrolase_dom-like.
 IPR015376; Znr_NADH_PPase. 

Pfam

 PF00293; NUDIX
 PF09296; NUDIX-like
 PF09297; zf-NADH-PPase 

SMART

 SM00248; ANK 

PROSITE

 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS51462; NUDIX
 PS00893; NUDIX_BOX 

PRINTS