Tag | Content |
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CPLM ID | CPLM-004229 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Fumarate hydratase, mitochondrial |
Protein Synonyms/Alias | Fumarase |
Gene Name | Fh |
Gene Synonyms/Alias | Fh1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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58 | YDTFGELKVPTDKYY | acetylation | [1] | 63 | ELKVPTDKYYGAQTV | acetylation | [1] | 77 | VRSTMNFKIGGATER | acetylation | [1] | 91 | RMPIPVIKAFGILKR | acetylation | [1] | 97 | IKAFGILKRAAAEVN | acetylation | [1] | 112 | QEYGLDPKIASAIMK | acetylation | [1] | 119 | KIASAIMKAADEVAE | acetylation | [1] | 128 | ADEVAEGKLNDHFPL | acetylation | [1] | 169 | LGGELGSKKPVHPND | acetylation | [1] | 170 | GGELGSKKPVHPNDH | acetylation | [1] | 220 | DALSAKSKEFAQVIK | acetylation | [1] | 289 | TRIGFAEKVAAKVAA | acetylation | [1] | 444 | ANTERINKLMNESLM | acetylation | [1] | 464 | NPHIGYDKAAKIAKT | acetylation | [1] | 467 | IGYDKAAKIAKTAHK | acetylation | [1] | 470 | DKAAKIAKTAHKNGS | acetylation | [1] | 499 | EQFDEWVKPKDMLGP | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | |
Sequence Annotation | REGION 173 176 B site (By similarity). REGION 183 185 Substrate binding (By similarity). BINDING 144 144 Substrate (By similarity). MOD_RES 63 63 N6-acetyllysine (By similarity). MOD_RES 77 77 N6-acetyllysine (By similarity). MOD_RES 91 91 N6-acetyllysine (By similarity). MOD_RES 112 112 N6-acetyllysine (By similarity). MOD_RES 289 289 N6-acetyllysine (By similarity). MOD_RES 474 474 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Alternative initiation; Complete proteome; Cytoplasm; Direct protein sequencing; Lyase; Mitochondrion; Reference proteome; Transit peptide; Tricarboxylic acid cycle. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 507 AA |
Protein Sequence | MNRAFCLLAR SRRFPRVPSA GAVLSGEAAT LPRCAPNVVR MASQNSFRIE YDTFGELKVP 60 TDKYYGAQTV RSTMNFKIGG ATERMPIPVI KAFGILKRAA AEVNQEYGLD PKIASAIMKA 120 ADEVAEGKLN DHFPLVVWQT GSGTQTNMNV NEVISNRAIE MLGGELGSKK PVHPNDHVNK 180 SQSSNDTFPT AMHIAAALEV HQVLLPGLQK LHDALSAKSK EFAQVIKIGR THTQDAVPLT 240 LGQEFSGYVQ QVQYAMERIK AAMPRIYELA AGGTAVGTGL NTRIGFAEKV AAKVAALTGL 300 PFVTAPNKFE ALAAHDALVE LSGAMNTTAC SLMKIANDIR FLGSGPRSGL GELILPENEP 360 GSSIMPGKVN PTQCEAMTMV AAQVMGNHVA VTVGGSNGHF ELNVFKPMMI KNVLHSARLL 420 GDASVSFTEN CVVGIQANTE RINKLMNESL MLVTALNPHI GYDKAAKIAK TAHKNGSTLK 480 KTAIELGYLT AEQFDEWVKP KDMLGPK 507 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:RGD. GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro. GO:0004333; F:fumarate hydratase activity; IDA:RGD. GO:0006106; P:fumarate metabolic process; IDA:RGD. GO:0006108; P:malate metabolic process; IDA:RGD. GO:0006099; P:tricarboxylic acid cycle; IDA:RGD. |
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Pfam | |
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PROSITE | |
PRINTS | |