CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005373
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Beige protein homolog 1 
Protein Synonyms/Alias
  
Gene Name
 BPH1 
Gene Synonyms/Alias
 YCR032W; YCR32W; YCR591; YCR601 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
450FEESTNSKNIPEVGKubiquitination[1]
1667SSYLIRLKPFVESFLubiquitination[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 
Functional Description
 May be involved in protein sorting and cell wall formation. 
Sequence Annotation
 DOMAIN 1545 1839 BEACH.
 REPEAT 1927 1965 WD 1.
 REPEAT 1976 2015 WD 2.
 REPEAT 2017 2054 WD 3.
 REPEAT 2072 2111 WD 4.
 REPEAT 2129 2167 WD 5.  
Keyword
 Complete proteome; Cytoplasm; Membrane; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2167 AA 
Protein Sequence
MNSIINAASK VLRLQDDVKK ATIILGDILI LQPINHEVEP DVENLVQHEL TKIIQGYPIQ 60
DNMIINSKKG TVEDDLCELN NYTCFALSKS FDLCHDSRNF NIAQPKRWIQ LLETLTDSVS 120
FAVIVQIILT LSNISLINKQ TLGKLKKLRI RIFEILSNKN DSWKSTLLQK NLIEWYIFML 180
SVDCTPLELQ NLYLHKELKF CNGILNSLTL QVSDPRSQNY LQFENTYKLF QIQKSSRINN 240
SFLFYIEFNS VTSNRIMTIE RHIYLEIKEG QFCISNDNYI IGLFENFEFE AGTLYFIGVL 300
IDHNNRITLY VDGSMINQLT LFENSICQLS TCELGSMICS IKVYRFYLWD GLLTEFAINI 360
LQAIGTNYQY TFSKKKEGPE VLSLCQDFLI AKAHLMARPT TEISSTKYID EIELLEMENI 420
IIDVNPNDIL QDFTESSNFT VKFEESTNSK NIPEVGKCYF YRSSNLVSKF VSIDSIRLAF 480
LNMTESGSID DLFHHVSHLM NLLRNIDILN WFKKDFGFPL FAYTLKQKIT QDLSQPLNIQ 540
FFNLFLEFCG WDFNDISKSI ILDTDAYENI VLNLDLWYMN EDQSSLASGG LEIIRFLFFQ 600
ISSLMEASIY SKFNSNKFND MNILEKLCLS YQAVTKRENQ NSKFNELSSD LISVFVTLLK 660
SNTDKRHLQW FLHLSYYFIK RKDVRSTEII LQAVDQLFSF YLDQGSDENA KILSEIIPLK 720
LILMIMDQIV ENNESNPITC LNILFKVVLT NKPLFKQFYK NDGLKLILTM LCKVGKSYRE 780
EIISLLLTYS IGNYTTANEI FSGAEDMIGG ISNDKITAKE IIYLAVNFIE WHVINSNASD 840
SSSVLDLNNH ILRFVEDLKS LSAVPINESV FDPKKSYVMV SLLDLSIALN ESEDISKFKS 900
SSKVISELIK GNIMCALTKY AAYDFEVYMS TFFCHSTEYK LVYPKTVMNN SSYLELSFIV 960
TLLPEILNDL VDSNNNLNLM MLKHPYTMSN LLYFLRKFRP DTSQIVMPKD FYFSSYTCLL 1020
HCVIQIDKSS FYHFKNVSKS QLLQDFKICI MNLIYSNTLK QIIWEKEEYE MFSESLMAHQ 1080
EVLFAHGACD NETVGLLLIF FANRLRDCGY NKAVFNCMKV IIKNKERKLK EVACFFDPAN 1140
KSEVLEGLSN ILSCNNSETM NLITEQYPFF FNNTQQVRFI NIVTNILFKN NNFSPISVRQ 1200
IKNQVYEWKN ARSEYVTQNN KKCLILFRKD NTSLDFKIKK SISRYTYNLK TDREENAVFY 1260
RNNLNLLIFH LKHTLEIQSN PNSSCKWSSD FAEDFDGMKR RLLPAWEPKY EPLINEEDAN 1320
QDTITGGNRQ RRESGSILSY EFIEHMETLE SEPVGDLNEN RKILRLLKDN DSIATIWNCS 1380
LIIGLEIKEG ILIHGSNYLY FVSDYYFSLE DKKILKLSEV SQESRDMTVS LINGPDVKRV 1440
STFLKHEVFV WKLLDITFVT KRPFLLRDVA IELLFKERVS AFFSFYNKRV RDDVLRVLNK 1500
IPKHLPADPI FSSVLQEIND RGNSIVARNG IGKASIASKF TSVFSANNSL IDGFEISKKW 1560
VRGEISNFYY LLSINILAGR SFNDLTQYPV FPWVIADYES NVLDLENPKT YRDLSKPMGA 1620
QSEKRKLQFI ERYEALASLE NADSAPFHYG THYSSAMIVS SYLIRLKPFV ESFLLLQGGS 1680
FGPADRLFSS LERAWSSASS ENTTDVRELT PEFFFLPEFL INVNSYDFGT DQSGKKVDDV 1740
VLPPWANGDP KVFIQKNREA LESPYVSAHL HEWIDLIFGY KQKGDIAVKS VNVFNRLSYP 1800
GAVNLDNIDD ENERRAITGI IHNFGQTPLQ IFQEPHPEKI ACNVQQLTTE VWRKVPMKPI 1860
FEKTIFNLNE KNRSVDYVIH DPSYFDSLYW RGFAFPNLFF RTEESLVSLR IVHKNWLKIG 1920
LDIFKKTHMA QITSFAYWKL GEFITGDKNG LIKVWKYRKD KHSVSGNLEN KKTMFGHLCE 1980
LKEMRCYHDY NTLLTLDISG LVYVWDMINF ELVRQITNDA QKVAISQHAG SIMVLTKNNA 2040
ISIFNLNGQI YTSKKFEPAK IVSSIDFFDF TKLDAGYRKH IYWKEMEILL VGFEDGTIEI 2100
YELFLNFHNE WAIKLLKQLC TEKGKAITSI KGQGKTYLSQ KRRKDTAEPH EIEVIAGTLD 2160
GRLAIWY 2167 
Gene Ontology
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0019898; C:extrinsic to membrane; IDA:SGD.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0031505; P:fungal-type cell wall organization; IMP:SGD.
 GO:0006886; P:intracellular protein transport; IMP:SGD.
 GO:0009268; P:response to pH; IMP:SGD. 
Interpro
 IPR000409; BEACH_dom.
 IPR023362; PH-BEACH_dom.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF02138; Beach 
SMART
 SM01026; Beach
 SM00320; WD40 
PROSITE
 PS50197; BEACH
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS