UniProt Accession

 RPAB3_YEAST; P20436; D6W2S9 

Genbank Protein ID

 X53289; X92441; Z75132; AY693087; BK006948 

Genbank Nucleotide ID

 CAA37383.1; CAA63187.1; CAA99443.1; AAT93106.1; DAA10995.1 

Protein Name

 DNA-directed RNA polymerases I, II, and III subunit RPABC3 

Protein Synonyms/Alias

 RNA polymerases I, II, and III subunit ABC3; ABC14.4; ABC14.5; DNA-directed RNA polymerases I, II, and III 14.5 kDa polypeptide 

Gene Name

 RPB8 

Gene Synonyms/Alias

 YOR224C; YOR50-14 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
136	YRNLNNLKQENAYLL	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. 

Sequence Annotation

 REGION 16 39 Non-specific ssDNA binding (By
 MOD_RES 68 68 Phosphothreonine.  

Keyword

 3D-structure; Complete proteome; DNA-binding; DNA-directed RNA polymerase; Nucleus; Phosphoprotein; Reference proteome; Transcription. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 146 AA 

Protein Sequence

Gene Ontology

 GO:0005736; C:DNA-directed RNA polymerase I complex; IDA:SGD.
 GO:0005665; C:DNA-directed RNA polymerase II, core complex; IDA:SGD.
 GO:0005666; C:DNA-directed RNA polymerase III complex; IDA:SGD.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
 GO:0006360; P:transcription from RNA polymerase I promoter; IDA:SGD.
 GO:0006366; P:transcription from RNA polymerase II promoter; IPI:SGD.
 GO:0042797; P:tRNA transcription from RNA polymerase III promoter; IDA:SGD. 

Interpro

 IPR012340; NA-bd_OB-fold.
 IPR005570; RNA_pol_Rpb8. 

Pfam

 PF03870; RNA_pol_Rpb8 

SMART

 SM00658; RPOL8c 

PROSITE

  

PRINTS