UniProt Accession

 SERA_YEAST; P40054; D3DLY8 

Genbank Protein ID

 U18839; BK006939 

Genbank Nucleotide ID

 AAB64636.1; DAA07742.1 

Protein Name

 D-3-phosphoglycerate dehydrogenase 1 

Protein Synonyms/Alias

 3-PGDH 1 

Gene Name

 SER3 

Gene Synonyms/Alias

 YER081W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
52	VKHPKILKPFSTGDM	acetylation	[1]
97	PEEELIEKIKDVHAI	acetylation	[1]
99	EELIEKIKDVHAIGI	acetylation	[1]
188	LHTGTWNKVAARCWE	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

  

Sequence Annotation

 DOMAIN 399 469 ACT.
 NP_BIND 208 209 NAD (By similarity).
 NP_BIND 285 287 NAD (By similarity).
 NP_BIND 347 350 NAD (By similarity).
 ACT_SITE 287 287 By similarity.
 ACT_SITE 316 316 By similarity.
 ACT_SITE 347 347 Proton donor (By similarity).
 BINDING 228 228 NAD (By similarity).
 BINDING 311 311 NAD (By similarity).
 MOD_RES 22 22 Phosphoserine.
 MOD_RES 29 29 Phosphoserine (By similarity).
 MOD_RES 33 33 Phosphoserine (By similarity).  

Keyword

 Amino-acid biosynthesis; Complete proteome; NAD; Oxidoreductase; Phosphoprotein; Reference proteome; Serine biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 469 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0004617; F:phosphoglycerate dehydrogenase activity; IMP:SGD.
 GO:0006564; P:L-serine biosynthetic process; IEA:UniProtKB-KW.
 GO:0009070; P:serine family amino acid biosynthetic process; IMP:SGD. 

Interpro

 IPR006139; D-isomer_2_OHA_DH_cat_dom.
 IPR006140; D-isomer_2_OHA_DH_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00389; 2-Hacid_dh
 PF02826; 2-Hacid_dh_C 

SMART

  

PROSITE

 PS51671; ACT
 PS00065; D_2_HYDROXYACID_DH_1
 PS00670; D_2_HYDROXYACID_DH_2
 PS00671; D_2_HYDROXYACID_DH_3 

PRINTS