UniProt Accession

 RS15_HUMAN; P62841; A5D8V9; P11174; Q3KRA1; Q9UDC2 

Genbank Protein ID

 J02984; M32405; AF145025; BC064908; BC105810; BC141832 

Genbank Nucleotide ID

 AAA36036.1; AAA36568.1; AAP97277.1; AAH64908.1; AAI05811.1; AAI41833.1 

Protein Name

 40S ribosomal protein S15 

Protein Synonyms/Alias

 RIG protein 

Gene Name

 RPS15 

Gene Synonyms/Alias

 RIG 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
7	*MAEVEQKKKRTFRK	ubiquitination	[1]
65	KRLRKAKKEAPPMEK	ubiquitination	[1, 2, 3]
72	KEAPPMEKPEVVKTH	ubiquitination	[1]
77	MEKPEVVKTHLRDMI	ubiquitination	[1, 3, 4, 5]
124	GEFSITYKPVKHGRP	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

  

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Reference proteome; Ribonucleoprotein; Ribosomal protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 145 AA 

Protein Sequence

Gene Ontology

 GO:0022627; C:cytosolic small ribosomal subunit; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; NAS:UniProtKB.
 GO:0003677; F:DNA binding; NAS:UniProtKB.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
 GO:0042274; P:ribosomal small subunit biogenesis; IMP:UniProtKB.
 GO:0000056; P:ribosomal small subunit export from nucleus; IMP:UniProtKB.
 GO:0006364; P:rRNA processing; IMP:UniProtKB.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
 GO:0006414; P:translational elongation; TAS:Reactome.
 GO:0006413; P:translational initiation; TAS:Reactome.
 GO:0006415; P:translational termination; TAS:Reactome.
 GO:0019083; P:viral transcription; TAS:Reactome. 

Interpro

 IPR002222; Ribosomal_S19.
 IPR020934; Ribosomal_S19_CS.
 IPR023575; Ribosomal_S19_SF.
 IPR005713; Ribosomal_S19A/S15e. 

Pfam

 PF00203; Ribosomal_S19 

SMART

  

PROSITE

 PS00323; RIBOSOMAL_S19 

PRINTS

 PR00975; RIBOSOMALS19.