CPLM-009445

Genbank Nucleotide ID

40S ribosomal protein S15a

Protein Synonyms/Alias

Homo sapiens (Human)

Position	Peptide	Type	References
12	NVLADALKSINNAEK	ubiquitination	[1, 2, 3]
19	KSINNAEKRGKRQVL	ubiquitination	[1, 2, 3]
32	VLIRPCSKVIVRFLT	ubiquitination	[1, 3]
60	IDDHRAGKIVVNLTG	ubiquitination	[1, 2, 3, 4]
71	NLTGRLNKCGVISPR	ubiquitination	[1, 2, 3, 4, 5]
84	PRFDVQLKDLEKWQN	ubiquitination	[1, 2, 3, 4, 5, 6]
88	VQLKDLEKWQNNLLP	ubiquitination	[1, 2, 3, 6]
124	RRKHTGGKILGFFF*	acetylation	[7, 8]
124	RRKHTGGKILGFFF*	ubiquitination	[1, 3]

[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
[5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
[6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
[7] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
[8] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]

Functional Description

3D-structure; Complete proteome; Direct protein sequencing; Reference proteome; Ribonucleoprotein; Ribosomal protein.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0022627; C:cytosolic small ribosomal subunit; IDA:UniProtKB.
GO:0005739; C:mitochondrion; IEA:Compara.
GO:0003723; F:RNA binding; NAS:UniProtKB.
GO:0003735; F:structural constituent of ribosome; IDA:UniProtKB.
GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
GO:0045787; P:positive regulation of cell cycle; IDA:UniProtKB.
GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.
GO:0009615; P:response to virus; IDA:UniProtKB.
GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
GO:0006414; P:translational elongation; TAS:Reactome.
GO:0006413; P:translational initiation; TAS:Reactome.
GO:0006415; P:translational termination; TAS:Reactome.
GO:0019083; P:viral transcription; TAS:Reactome.

IPR000630; Ribosomal_S8.

PF00410; Ribosomal_S8

PS00053; RIBOSOMAL_S8